Whole blood transcriptome reflects the circulating levels of glucocorticoids. FKBP5 expression could be a nonhormonal marker of Cushing's syndrome.

Read more at https://cushings.invisionzone.com/topic/57743-whole-blood-transcriptomic-signature-of-cushings-syndrome/

Dr. Friedman is an expert in pituitary, thyroid and adrenal issues as well as several other endocrine conditions, while most endocrinologists specialize in diabetes or just thyroid disease.  He has seen and diagnosed more patients with Cushing’s disease, growth hormone deficiency or adrenal insufficiency in a month than most Endocrinologists see in a lifetime.

https://cushings.invisionzone.com/topic/57822-reasons-you-or-your-friend-or-family-member-should-see-dr-friedman/

Amber is from New Zealand.  She was diagnosed with a pituitary tumor in 2020 , and underwent  surgery, several years after symptoms emerged, including rapid weight gain, muscle loss, brain fog, fatigue, depression and severe headaches.

Read more at https://cushingsbios.com/2022/12/11/amber-d-pituitary-bio/

The most common cause of Cushing syndrome (CS) is exposure to exogenous glucocorticoids. There is an increasing incidence of adulterated over-the-counter (OTC) supplements containing steroids.

Read more at https://cushings.invisionzone.com/topic/57624-exogenous-cushing-syndrome-and-hip-fracture-due-to-over-the-counter-supplement-artri-king/

The higher IGF-1 index was independently associated with lower prevalence of low bone mass in young CD patients, and IGF-1 might play an important role in the pathogenesis of CD-caused low bone mass.

Read more at https://cushings.invisionzone.com/topic/57619-association-of-igf-1-level-with-low-bone-mass-in-young-patients-with-cushing%E2%80%99s-disease/

Of the 40 women with Cushing’s syndrome, 32 were ACTH-dependent and the other eight were ACTH independent. Of the independent group, seven had adrenal adenoma and one had adrenocortical carcinoma.

Read more at https://cushings.invisionzone.com/topic/57623-bmd-may-underestimate-bone-deterioration-for-women-with-endogenous-cushing%E2%80%99s-syndrome/

Ectopic Cushing’s syndrome due to metastatic neuroendocrine small-cell carcinoma is a rare condition with a poor prognosis. The options for treatment are few and not necessarily curative. There needs to be increased awareness of this serious and rare complication. Managing the condition can be a challenge and requires a multidisciplinary team approach to improve outcomes.

Read more at https://cushings.invisionzone.com/topic/57577-recurrent-neuroendocrine-tumor-of-the-cervix-presenting-with-ectopic-cushing%E2%80%99s-syndrome/

Cushing syndrome (CS) is a rare disease caused by excess cortisol levels with high cardiovascular morbidity and mortality. Hypertension in CS promotes hypercortisolism-associated cardiovascular events.

Read more at https://cushings.invisionzone.com/topic/57633-unique-gene-expression-signature-in-periadrenal-adipose-tissue-identifies-a-high-blood-pressure-group-in-patients-with-cushing-syndrome/

Among the most common causes of moon face is Cushing's syndrome—a condition that occurs when your body makes too much cortisol, which is commonly referred to as the 'stress hormone.' One of the most common symptoms of Cushing's syndrome is moon face, but you might also experience darkening of the skin, weight gain, and muscle weakness.

Read more at https://cushings.invisionzone.com/topic/57665-basics-what-is-moon-face/

Cushing’s disease may sometimes make you feel that your life is out of your control. But there are some general things you can do to help take back control.

https://cushings-help.com/2024/11/05/tips-for-living-with-cushings/

Medications which are sometimes used to treat Cushing's

Read more at https://cushings.invisionzone.com/topic/56925-medications-used-to-treat-cushing%E2%80%99s/

Posterior pituitary tumors (PPTs) are extremely rare, with fewer than 400 cases reported to date. In 2022, the WHO classified four types of tumors originating from the posterior pituitary

Read more at https://cushings.invisionzone.com/topic/57780-oncocytic-pituicytoma-in-a-patient-with-cushings-disease/

IGF-1 is an important growth hormone, mediating the protein anabolic and linear growth promoting effect of pituitary GH. It has a GH independent growth stimulating effect, which with respect to cartilage cells is possibly optimised by the synergistic action with GH.

Read more at https://cushings.invisionzone.com/topic/56364-basics-testing-igf-1-insulin-like-growth-factor-1/

Transsphenoidal surgery is the first-line treatment for Cushing’s disease (CD), even with negative preoperative magnetic resonance imaging (MRI) results. Some patients with persistent or recurring hypercortisolism have negative MRI findings after the initial surgery. We aimed to analyze the efficacy of repeat surgery in two groups of patients and determine if there is an association between positive MRI findings and early remission.

Read more at https://cushings.invisionzone.com/topic/57583-reoperation-for-recurrent-and-persistent-cushing%E2%80%99s-disease-without-visible-mri-findings/

Dr. Friedman is an expert in pituitary, thyroid and adrenal issues as well as several other endocrine conditions, while most endocrinologists specialize in diabetes or just thyroid disease.  He has seen and diagnosed more patients with Cushing’s disease, growth hormone deficiency or adrenal insufficiency in a month than most Endocrinologists see in a lifetime.

https://cushings.invisionzone.com/topic/57822-reasons-you-or-your-friend-or-family-member-should-see-dr-friedman/

The most common cause of Cushing syndrome (CS) is exposure to exogenous glucocorticoids. There is an increasing incidence of adulterated over-the-counter (OTC) supplements containing steroids.

Read more at https://cushings.invisionzone.com/topic/57624-exogenous-cushing-syndrome-and-hip-fracture-due-to-over-the-counter-supplement-artri-king/

The higher IGF-1 index was independently associated with lower prevalence of low bone mass in young CD patients, and IGF-1 might play an important role in the pathogenesis of CD-caused low bone mass.

Read more at https://cushings.invisionzone.com/topic/57619-association-of-igf-1-level-with-low-bone-mass-in-young-patients-with-cushing%E2%80%99s-disease/

Intensity-Modulated Radiotherapy for Cushing’s Disease was a highly effective second-line therapy with low side effect profile for CD patients. Endocrine remission, tumor control and recurrence rates were comparable  to previous reports on FRT and SRS.

Read more at https://cushings.invisionzone.com/topic/57645-intensity-modulated-radiotherapy-for-cushing%E2%80%99s-disease-single-center-experience-in-70-patients/

Ectopic Cushing’s syndrome due to metastatic neuroendocrine small-cell carcinoma is a rare condition with a poor prognosis. The options for treatment are few and not necessarily curative. There needs to be increased awareness of this serious and rare complication. Managing the condition can be a challenge and requires a multidisciplinary team approach to improve outcomes.

Read more at https://cushings.invisionzone.com/topic/57577-recurrent-neuroendocrine-tumor-of-the-cervix-presenting-with-ectopic-cushing%E2%80%99s-syndrome/

Like most everything else in my life, having had Cushing's (pituitary) made this surgery more difficult.  My surgeon had to plan with my endocrinologist how much cortisol I'd need during the operation, then I had to stay overnight to get me successfully weaned off the cortisone again.

Read more at https://cushings.invisionzone.com/topic/57682-what-was-the-most-memorable-thing-that-happened-to-you-last-year/

Our study demonstrated that osilodrostat therapy in patients with CPA may require a different approach than that in CD, with higher doses, faster dose escalation, and a possible initial inverse response or lack of response.

Read more at https://cushings.invisionzone.com/topic/57715-response-to-osilodrostat-therapy-in-adrenal-cushing%E2%80%99s-syndrome/

Listen as Robin Smith (staticnrg) and Mary O’Connor (MaryO) co-host Cushing’s message board members calling in to talk about their fight for diagnosis and treatment. The show will be opened with a brief explanation of what Cushing’s is and what the symptoms are.

Listen at https://cushieblogger.com/2022/04/12/archived-interview-cushings-diagnosis-and-symptoms-part-2-2/

Cushing’s disease may sometimes make you feel that your life is out of your control. But there are some general things you can do to help take back control.

https://cushings-help.com/2024/11/05/tips-for-living-with-cushings/

Cushing disease and acromegaly are common endocrine disorders caused by excessive cortisol and growth hormone production, respectively. Both conditions can co-occur due to functioning pituitary adenomas, which are typically benign pituitary gland tumors. This report discusses a 30-year-old woman with hyperpituitarism leading to treatment-resistant Cushing disease and acromegaly caused by a functional pituitary macroadenoma.

https://cushings.invisionzone.com/topic/57793-treatment-resistant-cushing-disease-and-acromegaly-in-a-young-woman-a-case-of-functional-pituitary-macroadenoma/

Robin had Cushing's for over 20 years, at least. Of course, no one figured it out or even put two and two together until her new PCP whom she found in 2004 said 'endocrine'. She didn't figure it out, either, but at least Robin had a piece of the puzzle and she found cushings-help.com. Robin immediately went into denial and left for several months until she got so sick she knew she had to have help. She had originally sought this PCP because she had been going to all sorts of doctors.

Read more at https://cushieblogger.com/2022/04/13/mary-oconnor-maryo-second-archived-interview-with-robin-smith-staticnrg-2/

Posterior pituitary tumors (PPTs) are extremely rare, with fewer than 400 cases reported to date. In 2022, the WHO classified four types of tumors originating from the posterior pituitary

Read more at https://cushings.invisionzone.com/topic/57780-oncocytic-pituicytoma-in-a-patient-with-cushings-disease/

On December 26, 2014 she went to a local urgent care clinic with pneumonia, confirmed by an x-ray, for which she was treated.  Carola received a phone call from the urgent care clinic a few days afterwards explaining that the radiologist had seen something unusual that needed further examination.  

After numerous tests her suspected Cushing’s diagnosis was confirmed.

Read more at https://cushingsbios.com/2022/06/12/carola-b-carola-adrenal-bio/

Spontaneous remission of Cushing’s disease (CD) is uncommon and often attributed to pituitary tumor apoplexy. We present a case involving a 14-year-old female who exhibited clinical features of Cushing’s syndrome.

Read more at https://cushings.invisionzone.com/topic/57744-spontaneous-cushing%E2%80%99s-disease-remission-induced-by-pituitary-apoplexy/

The Add Your Bio form has been updated so that it no longer requires Flash. Your information will help others.

I would like to add that if anyone would like to do something for the Cushing's Awareness Challenge but you don't have (or want to have) a blog, why not consider adding your bio to the website this month?

More info at https://cushingsbios.com/2018/08/28/we-have-a-new-bio-form/

Dr. Friedman is an expert in pituitary, thyroid and adrenal issues as well as several other endocrine conditions, while most endocrinologists specialize in diabetes or just thyroid disease.  He has seen and diagnosed more patients with Cushing’s disease, growth hormone deficiency or adrenal insufficiency in a month than most Endocrinologists see in a lifetime.

https://cushings.invisionzone.com/topic/57822-reasons-you-or-your-friend-or-family-member-should-see-dr-friedman/

The most common cause of Cushing syndrome (CS) is exposure to exogenous glucocorticoids. There is an increasing incidence of adulterated over-the-counter (OTC) supplements containing steroids.

Read more at https://cushings.invisionzone.com/topic/57624-exogenous-cushing-syndrome-and-hip-fracture-due-to-over-the-counter-supplement-artri-king/

The higher IGF-1 index was independently associated with lower prevalence of low bone mass in young CD patients, and IGF-1 might play an important role in the pathogenesis of CD-caused low bone mass.

Read more at https://cushings.invisionzone.com/topic/57619-association-of-igf-1-level-with-low-bone-mass-in-young-patients-with-cushing%E2%80%99s-disease/

Ectopic Cushing’s syndrome due to metastatic neuroendocrine small-cell carcinoma is a rare condition with a poor prognosis. The options for treatment are few and not necessarily curative. There needs to be increased awareness of this serious and rare complication. Managing the condition can be a challenge and requires a multidisciplinary team approach to improve outcomes.

Read more at https://cushings.invisionzone.com/topic/57577-recurrent-neuroendocrine-tumor-of-the-cervix-presenting-with-ectopic-cushing%E2%80%99s-syndrome/

A difference in peak postoperative plasma copeptin as an early marker to predict remission of CD was not consistently present, although the data point to the need for a larger sample size to further evaluate this. However, the utility of this test may be limited to those who develop neither DI nor SIADH postoperatively.

Read more at https://cushings.invisionzone.com/topic/56900-copeptin-levels-before-and-after-transsphenoidal-surgery-for-cushing-disease-a-potential-early-marker-of-remission/

I was then fortunate to continue my clinical training at University of Virginia with several giants of neurosurgery, and I was greatly influenced by the meticulous approach of Dr. Ed Oldfield’s pituitary surgeries, particularly for Cushing’s disease. It was such a joy to watch his precise extracapsular tumor resections. At the same time, I had become totally enchanted by the endoscopic endonasal operations that Dr. Amin Kassam was performing at University of Pittsburgh, and after many requests he finally accepted me for specialized training with him and his team. That was a life changing event for me, as my career was about to be centered in the development and refinement of endoscopic endonasal skull base and pituitary surgery.

Read more at  https://cushings.invisionzone.com/topic/57673-dr-fernandez-miranda/

Cushing’s disease may sometimes make you feel that your life is out of your control. But there are some general things you can do to help take back control.

https://cushings-help.com/2024/11/05/tips-for-living-with-cushings/

We'll periodically post basic Cushing's info here - along with updated info if available.

Please feel free to ask questions to learn more about Cushing's, testing, treatments and such.

Find it at https://cushings.invisionzone.com/forum/321-cushings-basics/

Findling ordered a dotatate PET scan to find where Houser's tumor was, finding it in her left lung. Ultimately, after much deliberation, Houser elected to undergo surgery to remove part of her left lung. A pathologist found the tumor was a rare, slow-growing neuroendocrine lung cancer known as bronchial carcinoid, which can cause Cushing's.

Read more at https://cushingsbios.com/2023/11/13/bridget-h-ectopic-cushings/

In conclusion, metformin inhibits tumor progression and ACTH secretion, potentially through suppression of the MAPK pathway in AtT20 cell lines. These findings suggest metformin as a potential drug for the treatment of Cushing's disease.

Read more at https://cushings.invisionzone.com/topic/57684-metformin-inhibits-cell-proliferation-and-acth-secretion-inatt20-cells-via-regulating-the-mapk-pathway/

Cushing’s syndrome is a constellation of features occurring due to high blood cortisol levels. We report a case of a 47-year-old male with a history of recurrent olfactory neuroblastoma (ONB). He presented with bilateral lower limb weakness and anosmia and was found to have Cushing’s syndrome due to high adrenocorticotropic hormone (ACTH) levels from an ectopic source, ONB in this case. Serum cortisol and ACTH levels declined after tumor removal.

Read more at https://cushings.invisionzone.com/topic/57716-olfactory-neuroblastoma-causing-cushing%E2%80%99s-syndrome-due-to-the-ectopic-adrenocorticotropic-hormone-acth-secretion/

Posterior pituitary tumors (PPTs) are extremely rare, with fewer than 400 cases reported to date. In 2022, the WHO classified four types of tumors originating from the posterior pituitary

Read more at https://cushings.invisionzone.com/topic/57780-oncocytic-pituicytoma-in-a-patient-with-cushings-disease/

Crooke cell adenomas (CCA) are a rare, aggressive subset of adrenocorticotrophin secreting pituitary corticotroph adenomas (sCTA) found in 5–10% of patients with Cushing’s disease. Multiple studies support worse outcomes in CCA but are limited by small sample size and single-institution databases. We compared outcomes in CCA and sCTA using a multicenter, international retrospective database of high-volume skull base centers.

Read more at https://cushings.invisionzone.com/topic/57646-crooke-cell-adenoma-confers-poorer-endocrinological-outcomes-compared-with-corticotroph-adenoma/

Since 1987, NORD has provided assistance programs to help patients obtain life-saving or life-sustaining medication they could not otherwise afford. These programs provide medication, financial assistance with insurance premiums and co-pays, diagnostic testing assistance, and travel assistance for clinical trials or consultation with disease specialists.

Read more at https://cushings.invisionzone.com/topic/56948-need-help-paying-for-your-meds/

Add your own info (or your doctor's) to the Cushie MemberMap at https://cushieblogger.com/2018/11/17/rebuilding-the-membermap/

A worldwide, observational study of adults and adolescents with growth hormone deficiency (GHD) found long-term GH replacement was safe. These findings were published in the Journal of Clinical Endocrinology & Metabolism.

…

The most common all-cause adverse events included arthralgia (4.6%), peripheral edema (3.9%), headache (3.6%), influenza (2.8%), depression (2.8%), and recurrence of pituitary tumor (2.7%). The most common treatment-related adverse events were peripheral edema (3.1%) and arthralgia (2.6%).

Read more at https://cushings.invisionzone.com/topic/56901-safety-of-long-term-growth-hormone-treatment-assessed/

Cushing’s disease (CD) is an extremely rare diagnosis in children. In this report, we present the case of an almost 16-year-old, short and thin boy with CD, the first symptoms of which were spinal pain and vertebral fractures as a result of osteoporosis. In light of his growth retardation and short stature, the boy underwent diagnostics, which excluded growth hormone (GH) deficiency, hypothyroidism and celiac disease. Finally, based on cortisol profile results, dexamethasone suppression tests and bilateral sampling during catheterization of the inferior petrosal sinuses, CD was diagnosed.

Read more at https://cushings.invisionzone.com/topic/57647-osteoporosis-as-the-first-sign-of-cushing%E2%80%99s-disease-in-a-thin-16-year-old-boy/

We report the case of a 53-year-old female patient who presented with severe Cushing’s syndrome and was diagnosed with ectopic ACTH syndrome. Despite initial indications pointing towards pituitary-dependent hypercortisolism, further investigations revealed the presence of a highly differentiated atypically located tumor in the upper lobe of the left lung, adjacent to the mediastinum. Immunohistochemistry of the tumor tissue demonstrated not only ACTH but also CRH and CRH-R1 expression.

https://cushings.invisionzone.com/topic/57795-ectopic-crhacth-co-secreting-neuroendocrine-tumors-leading-to-cushings-disease/

Cushing’s syndrome with concurrent primary aldosteronism (PA) is a rare presentation, and establishing an early diagnosis is imperative to preventing morbidity and long-term sequelae. The diagnosis is established by sequential lab work, showing an elevated cortisol and aldosterone level.

Read more at https://cushings.invisionzone.com/topic/57634-rare-challenges-in-diagnosing-cushing%E2%80%99s-syndrome-and-primary-aldosteronism-a-case-report-of-a-female-with-a-negative-workup/

Bone material properties remain altered in patients with endogenous CS, even after long-term remission. These abnormalities, known to be associated with fractures in other populations, may play a role in the persistent bone fragility of steroid excess.

https://cushings.invisionzone.com/topic/57772-bone-material-strength-index-is-low-in-patients-with-cushings-syndrome-even-after-long-term-remission/

Dr. Friedman is an expert in pituitary, thyroid and adrenal issues as well as several other endocrine conditions, while most endocrinologists specialize in diabetes or just thyroid disease.  He has seen and diagnosed more patients with Cushing’s disease, growth hormone deficiency or adrenal insufficiency in a month than most Endocrinologists see in a lifetime.

https://cushings.invisionzone.com/topic/57822-reasons-you-or-your-friend-or-family-member-should-see-dr-friedman/

The most common cause of Cushing syndrome (CS) is exposure to exogenous glucocorticoids. There is an increasing incidence of adulterated over-the-counter (OTC) supplements containing steroids.

Read more at https://cushings.invisionzone.com/topic/57624-exogenous-cushing-syndrome-and-hip-fracture-due-to-over-the-counter-supplement-artri-king/

The higher IGF-1 index was independently associated with lower prevalence of low bone mass in young CD patients, and IGF-1 might play an important role in the pathogenesis of CD-caused low bone mass.

Read more at https://cushings.invisionzone.com/topic/57619-association-of-igf-1-level-with-low-bone-mass-in-young-patients-with-cushing%E2%80%99s-disease/

Ectopic Cushing’s syndrome due to metastatic neuroendocrine small-cell carcinoma is a rare condition with a poor prognosis. The options for treatment are few and not necessarily curative. There needs to be increased awareness of this serious and rare complication. Managing the condition can be a challenge and requires a multidisciplinary team approach to improve outcomes.

Read more at https://cushings.invisionzone.com/topic/57577-recurrent-neuroendocrine-tumor-of-the-cervix-presenting-with-ectopic-cushing%E2%80%99s-syndrome/

Cushing's syndrome (CS) is a rare disease with multiple somatic signs and a high prevalence of co-occurring depression. However, the characteristics of depression secondary to CS and the differences from major depression have not been described in detail. In this case, we report a 17-year-old girl with treatment-resistant depression with a series of atypical features and acute psychotic episodes, which is a rare condition secondary to CS.

Read more at https://cushings.invisionzone.com/topic/57625-treatment-resistant-depression-with-acute-psychosis-in-an-adolescent-girl-with-cushings-syndrome/

Cushing’s disease may sometimes make you feel that your life is out of your control. But there are some general things you can do to help take back control.

https://cushings-help.com/2024/11/05/tips-for-living-with-cushings/

One area where the problem of medical gaslighting is a huge issue is in the area of autoimmune diseases. So, we know that almost 80% of autoimmune disease sufferers are women, and there hasn't been nearly enough research into how to diagnose some of these diseases and how to recognize their symptoms. And as a result, a lot of women with autoimmune diseases say that when they have first gone to doctors, their symptoms have been dismissed, or doctors have said, 'It's just anxiety -- maybe you should go on an antidepressant,' something like that.

Express your thoughts at https://cushings.invisionzone.com/topic/56824-what-do-you-think-women-patients-of-color-warning-about-medical-gaslighting/

Posterior pituitary tumors (PPTs) are extremely rare, with fewer than 400 cases reported to date. In 2022, the WHO classified four types of tumors originating from the posterior pituitary

Read more at https://cushings.invisionzone.com/topic/57780-oncocytic-pituicytoma-in-a-patient-with-cushings-disease/

Anita is from Rye, Colorado

She was diagnosed with Cushing's in the summer of 2020 and now has an adrenal adenoma on heright.

Read more at https://cushingsbios.com/2022/10/15/anita-s-adrenal-bio/

Pasireotide is the first pituitary-directed approved therapy for Cushing’s disease (CD), effective in reducing 24 h urine free cortisol (UFC) > 50% in more than half of patients, with beneficial effects and with a relatively high incidence of hyperglycemia. The aim of this study was to evaluate efficacy and safety of long-term treatment with pasireotide (PAS) in CD patients, also according to gender.

https://cushings.invisionzone.com/topic/57812-efficacy-and-safety-of-pasireotide-in-patients-with-cushing%E2%80%99s-disease/

Cushing's awareness discussions come out in the oddest ways.

Last night, we were out at a Lebanese restaurant couple with a young couple from India and were talking about foods we liked.  I said that I liked spicy foods in general.

That led to the fact that I haven't had a good sense of smell since my transsphenoidal surgery and that things taste better when I can smell them.  That got us around to why I'd had the surgery and what the symptoms of Cushing's are....

Read more at https://cushings.invisionzone.com/topic/56835-day-15-cushing%E2%80%99s-awareness-challenge-2022/?do=findComment&comment=478739

Dr. Friedman is an expert in pituitary, thyroid and adrenal issues as well as several other endocrine conditions, while most endocrinologists specialize in diabetes or just thyroid disease.  He has seen and diagnosed more patients with Cushing’s disease, growth hormone deficiency or adrenal insufficiency in a month than most Endocrinologists see in a lifetime.

https://cushings.invisionzone.com/topic/57822-reasons-you-or-your-friend-or-family-member-should-see-dr-friedman/

The most common cause of Cushing syndrome (CS) is exposure to exogenous glucocorticoids. There is an increasing incidence of adulterated over-the-counter (OTC) supplements containing steroids.

Read more at https://cushings.invisionzone.com/topic/57624-exogenous-cushing-syndrome-and-hip-fracture-due-to-over-the-counter-supplement-artri-king/

The higher IGF-1 index was independently associated with lower prevalence of low bone mass in young CD patients, and IGF-1 might play an important role in the pathogenesis of CD-caused low bone mass.

Read more at https://cushings.invisionzone.com/topic/57619-association-of-igf-1-level-with-low-bone-mass-in-young-patients-with-cushing%E2%80%99s-disease/

Cushing’s disease is a progressive pituitary disorder in which there is an excess of cortisol in the body. While the disease can be treated surgically, this option is not possible for all patients. This is one of the approved medications that assist in controlling cortisol levels in people with Cushing’s disease.

Korlym (mifepristone), developed and marketed by Corcept Therapeutics, is an FDA-approved treatment for high blood sugar (hyperglycemia) in adults with Cushing’s syndrome who have type 2 diabetes or glucose intolerance, and for whom surgery is not an option, or failed to control their symptoms.

Read more at https://cushings.invisionzone.com/topic/56598-basics-meds-korlym/

Ectopic Cushing’s syndrome due to metastatic neuroendocrine small-cell carcinoma is a rare condition with a poor prognosis. The options for treatment are few and not necessarily curative. There needs to be increased awareness of this serious and rare complication. Managing the condition can be a challenge and requires a multidisciplinary team approach to improve outcomes.

Read more at https://cushings.invisionzone.com/topic/57577-recurrent-neuroendocrine-tumor-of-the-cervix-presenting-with-ectopic-cushing%E2%80%99s-syndrome/

Cushing syndrome characteristically presents with skin changes such as facial plethora, easy bruising, and purple striae and with metabolic manifestations such as hyperglycemia, hypertension, and excess fat deposition in the face, back of the neck, and visceral organs. 

Read more at https://cushings.invisionzone.com/topic/57616-basics-cushing-syndrome-a-review/

The purpose was to assess coronary inflammation by measuring the volume and density of the epicardial adipose tissue (EAT), perivascular fat attenuation index (FAI) and coronary plaque burden in patients with Cushing’s syndrome (CS) based on coronary computed tomography angiography (CCTA).

Read more at https://cushings.invisionzone.com/topic/57700-epicardial-and-pericoronary-adipose-tissue-and-coronary-plaque-burden-in-patients-with-cushing%E2%80%99s-syndrome/

What should you do if an Addison crisis threatens? How do you prepare an emergency injection and how do you administer it? 

See the video clip at http://cushings.invisionzone.com/topic/55250-important-how-an-emergency-injection-works/

Cushing’s disease may sometimes make you feel that your life is out of your control. But there are some general things you can do to help take back control.

https://cushings-help.com/2024/11/05/tips-for-living-with-cushings/

Primary pigmented nodular adrenocortical disease (PPNAD) is a rare but important cause of adrenocorticotropic hormone (ACTH)-independent Cushing syndrome (CS). It usually presents as cyclical CS in young adults. Childhood onset of PPNAD is exceedingly rare. About 90% of cases of PPNAD are associated with Carney complex (CNC).

https://cushings.invisionzone.com/topic/57796-a-rare-case-of-prkaca-duplication%E2%80%93associated-childhood-onset-primary-pigmented-nodular-adrenocortical-disease/

Posterior pituitary tumors (PPTs) are extremely rare, with fewer than 400 cases reported to date. In 2022, the WHO classified four types of tumors originating from the posterior pituitary

Read more at https://cushings.invisionzone.com/topic/57780-oncocytic-pituicytoma-in-a-patient-with-cushings-disease/

Jenn (StaceyJenn) was diagnosed with adrenal insufficiency, hypothyroidism, and a host of other ailments in 2001 (candidiasis, intestinal permeability, 22 latent food allergies). Once diagnosed, she was on specially formulated hydrocortisone for 7 years as she was allergic to the fillers in the meds...

Listen at https://cushieblogger.com/2019/04/15/archived-interview-jenn-steroid-induced-iatrogenic-cushings-patient/

This study suggests that BIPSS may be a reliable and low-complication technique in evaluating patients with ACTH-dependent CS who had inconclusive imaging and biochemical test results. The diagnostic accuracy is improved by DDAVP stimulation. Pituitary adenoma lateralization can be predicted with the aid of BIPSS.

Read more at https://cushings.invisionzone.com/topic/57666-bilateral-inferior-petrosal-sinus-sampling-validity-diagnostic-accuracy-in-lateralization-of-pituitary-microadenoma-and-treatment-in-eleven-patients-with-cushing%E2%80%99s-syndrome-%E2%80%93-a-single-center-retrospective-cohort-study/

The tumour affected teenager Niall’s pituitary gland, resulting in a condition known as hypopituitarism.

Read more at https://cushingsbios.com/2023/10/16/teenager-overcomes-brain-tumour-and-shares-his-experience-hypopituitarism/

In Cushing syndrome (CS), prolonged exposure to high cortisol levels results in a wide range of devastating effects causing multisystem morbidity. 

Read more at https://cushings.invisionzone.com/topic/57717-epigenetic-mechanisms-modulated-by-glucocorticoids-with-a-focus-on-cushing-syndrome/

Boy, I really needed to reread this again today.

Many thanks again...to me!...for sharing.

Except for my new 'hobby' of learning the balalaika, everything is seeming painful, blah, boring and, at times, plain annoying.

Read more at https://cushings.invisionzone.com/topic/56844-day-16-cushing%E2%80%99s-awareness-challenge-2022/?do=findComment&comment=478742

Dr. Correa has special expertise in transgender medicine; neuroendocrinology; and caring for adults with adrenal disorders, such as Cushing's syndrome, Addison's disease, primary hyperaldosteronism, neuroendocrine tumors, and rare endocrine conditions.

Read more at https://cushings.invisionzone.com/topic/57652-helpful-doctors-ricardo-correa/

Dr. Friedman is an expert in pituitary, thyroid and adrenal issues as well as several other endocrine conditions, while most endocrinologists specialize in diabetes or just thyroid disease.  He has seen and diagnosed more patients with Cushing’s disease, growth hormone deficiency or adrenal insufficiency in a month than most Endocrinologists see in a lifetime.

https://cushings.invisionzone.com/topic/57822-reasons-you-or-your-friend-or-family-member-should-see-dr-friedman/

Video, personal stories and 'official information'. 

The MRI still showed nothing, so they did a Petrosal Sinus Sampling Test. That scared me more than the prospect of surgery. (This test carries the risk of stroke and uncontrollable bleeding from the incision points.)

Catheters were fed from my groin area to my pituitary gland and dye was injected. I could watch the whole procedure on monitors. I could not move during this test or for several hours afterwards to prevent uncontrollable bleeding from a major artery.

The test did show where the tumor probably was located...

Read more at https://cushings.invisionzone.com/topic/56225-testing-inferior-petrosal-sinus-sampling/

The goal is to leave some normal adrenal tissue so that the patient can avoid adrenal insufficiency which requires a daily dose of several adrenal hormones and steroids. Partial adrenal surgery is especially beneficial for patients with pheochromocytoma, as well as Conn's and Cushing's syndrome. Avoiding daily steroids is life-changing for these patients so this is a major breakthrough.'

Read more at https://cushings.invisionzone.com/topic/56841-novel-application-of-amniotic-membrane-saves-adrenal-tissue-in-patients-undergoing-adrenal-surgery/

The most common cause of Cushing syndrome (CS) is exposure to exogenous glucocorticoids. There is an increasing incidence of adulterated over-the-counter (OTC) supplements containing steroids.

Read more at https://cushings.invisionzone.com/topic/57624-exogenous-cushing-syndrome-and-hip-fracture-due-to-over-the-counter-supplement-artri-king/

I have a tumour on my right adrenal gland and diagnosed with Cushings 3 years ago . Covid got in the way of surgery initially so now I wait and I wait. I try to keep going but I really just want to stay in bed as I’ve little energy, poor concentration and less interest…

Read more at https://cushingsbios.com/2016/08/23/niamh-niamhiblog-adrenal-bio/

The higher IGF-1 index was independently associated with lower prevalence of low bone mass in young CD patients, and IGF-1 might play an important role in the pathogenesis of CD-caused low bone mass.

Read more at https://cushings.invisionzone.com/topic/57619-association-of-igf-1-level-with-low-bone-mass-in-young-patients-with-cushing%E2%80%99s-disease/

Ectopic Cushing’s syndrome due to metastatic neuroendocrine small-cell carcinoma is a rare condition with a poor prognosis. The options for treatment are few and not necessarily curative. There needs to be increased awareness of this serious and rare complication. Managing the condition can be a challenge and requires a multidisciplinary team approach to improve outcomes.

Read more at https://cushings.invisionzone.com/topic/57577-recurrent-neuroendocrine-tumor-of-the-cervix-presenting-with-ectopic-cushing%E2%80%99s-syndrome/

Pheochromocytoma and Cushing's syndrome are rare endocrine conditions caused by tumors in the adrenal gland. These conditions are classified under Multiple Endocrine Neoplasia (MEN) syndrome...

Read more at https://cushings.invisionzone.com/topic/57627-asymptomatic-pheochromocytoma-associated-with-men-syndrome-and-subclinical-cushings-syndrome/

Pseudo-Cushing’s syndrome is when symptoms are similar to those of Cushing’s syndrome, but further tests show that the syndrome is not present.

Read more at https://cushings.invisionzone.com/topic/57556-basics-pseudo-cushing%E2%80%99s-syndrome/

Cushing’s syndrome is associated with early medical- and surgical-related complications following total joint arthroplasty and a reduced incidence of manipulation under anesthesia following total knee arthroplasty.

Read more at https://cushings.invisionzone.com/topic/57607-cushing%E2%80%99s-syndrome-is-associated-with-early-medical-and-surgical-related-complications-following-total-joint-arthroplasty/

Cushing’s disease may sometimes make you feel that your life is out of your control. But there are some general things you can do to help take back control.

https://cushings-help.com/2024/11/05/tips-for-living-with-cushings/

Doctors should suspect Cushing’s syndrome when they see patients with purple stretch marks and metabolic conditions such as diabetes, even if those symptoms aren’t the reasons for a medical visit, physicians in Japan wrote in a case study describing how they reached that diagnosis for a woman in her early 30s.

Read more at https://cushings.invisionzone.com/topic/57701-violaceous-abdominal-striae-noted-on-physical-examination-a-clue-to-the-diagnosis-of-cushing%E2%80%99s-syndrome/

A lot of Cushing’s patients are getting diagnosed and treated in primary care, which is completely appropriate. But I’ve also met endocrinologists who are uncomfortable diagnosing and managing Cushing’s because it is so rare,” she said.

Read more at https://cushings.invisionzone.com/topic/57755-insights-on-diagnosing-and-managing-cushing%E2%80%99s-syndrome/

Patients with endogenous Cushing’s syndrome (CS) have elevated mortality, particularly during active disease. A recent meta-analysis reported reduced mortality rates after 2000 in adrenal CS and Cushing disease (CD), though many studies lacked population-matched controls.

https://cushings.invisionzone.com/topic/57813-mortality-in-cushing%E2%80%99s-syndrome-declining-over-two-decades-but-remaining-higher-than-the-general-population/

Posterior pituitary tumors (PPTs) are extremely rare, with fewer than 400 cases reported to date. In 2022, the WHO classified four types of tumors originating from the posterior pituitary

Read more at https://cushings.invisionzone.com/topic/57780-oncocytic-pituicytoma-in-a-patient-with-cushings-disease/

Terry (Terry) is a long time pituitary Cushing’s survivor. Terry had a pituitary surgery (in LA) in October of 2003 which did not cure her Cushing’s Disease. Then, Dec 13th, 2003 she had her BLA in a Wisconsin hospital. She also had an infection in her sphenoid sinus. It originated at the site of her pituitary surgery from October 2003. She had to be on a lot of antibiotics and narcotic pain relievers. In Sept 2005 the surgeon remove the infection from one area, making another area clear…..

Listen at  https://cushieblogger.com/2019/04/16/archived-interview-terry-g-pituitary-patient/

Dr. Friedman is an expert in pituitary, thyroid and adrenal issues as well as several other endocrine conditions, while most endocrinologists specialize in diabetes or just thyroid disease.  He has seen and diagnosed more patients with Cushing’s disease, growth hormone deficiency or adrenal insufficiency in a month than most Endocrinologists see in a lifetime.

https://cushings.invisionzone.com/topic/57822-reasons-you-or-your-friend-or-family-member-should-see-dr-friedman/

The most common cause of Cushing syndrome (CS) is exposure to exogenous glucocorticoids. There is an increasing incidence of adulterated over-the-counter (OTC) supplements containing steroids.

Read more at https://cushings.invisionzone.com/topic/57624-exogenous-cushing-syndrome-and-hip-fracture-due-to-over-the-counter-supplement-artri-king/

CS is treated through surgical procedures based on the detected lesions. Patients with severe CS are treated with steroidogenic inhibitors, such as metyrapone, ketoconazole, osilodrostat, and mitotane. Pituitary radiotherapy and bilateral adrenalectomy are performed when other treatments are not effective.

Read more at https://cushings.invisionzone.com/topic/57649-hormones-and-high-blood-pressure-study-reveals-endocrine-culprits-and-targeted-treatments/

The higher IGF-1 index was independently associated with lower prevalence of low bone mass in young CD patients, and IGF-1 might play an important role in the pathogenesis of CD-caused low bone mass.

Read more at https://cushings.invisionzone.com/topic/57619-association-of-igf-1-level-with-low-bone-mass-in-young-patients-with-cushing%E2%80%99s-disease/

Ectopic Cushing’s syndrome due to metastatic neuroendocrine small-cell carcinoma is a rare condition with a poor prognosis. The options for treatment are few and not necessarily curative. There needs to be increased awareness of this serious and rare complication. Managing the condition can be a challenge and requires a multidisciplinary team approach to improve outcomes.

Read more at https://cushings.invisionzone.com/topic/57577-recurrent-neuroendocrine-tumor-of-the-cervix-presenting-with-ectopic-cushing%E2%80%99s-syndrome/

Like most everything else in my life, having had Cushing's (pituitary) made this surgery more difficult.  My surgeon had to plan with my endocrinologist how much cortisol I'd need during the operation, then I had to stay overnight to get me successfully weaned off the cortisone again.

Read more at https://cushings.invisionzone.com/topic/57682-what-was-the-most-memorable-thing-that-happened-to-you-last-year/

I had the opportunity to be in both Fair Oaks Emergency Room and the hospital in Fairfax, VA over the last couple days.  Whenever a nurse/medical tech mentioned steroids, I asked what they knew about Cushing's.  One asked if it was a medication.  DUH!…

Read more at https://cushings.invisionzone.com/topic/57694-spreading-the-word/

Cushing's disease causes numerous metabolic disorders, cognitive decline, and sarcopenia, leading to deterioration of the general health in older individuals. Cushing's disease can be treated with transsphenoidal surgery, but thus far, surgery has often been avoided in older patients.

Read more at https://cushings.invisionzone.com/topic/57005-transsphenoidal-surgery-in-an-older-patient-with-cushings-disease/

Among 89 patients enrolled in this study (median age, 51 years), 21 showed clinical signs of Cushing syndrome (overt hypercortisolism) and 68 did not show clinical presentations (subclinical hypercortisolism).

Read more at https://cushings.invisionzone.com/topic/57584-association-between-aldosterone-and-hypertension-among-patients-with-overt-and-subclinical-hypercortisolism/

Cushing’s disease may sometimes make you feel that your life is out of your control. But there are some general things you can do to help take back control.

https://cushings-help.com/2024/11/05/tips-for-living-with-cushings/

At diagnosis, CS patients have elevated WBC, neutrophils, and NLR compared to controls. Remission does not normalize WBC levels in all patients, and baseline leukocytosis predicts a poorer remission prognosis in CD.

https://cushings.invisionzone.com/topic/57797-leukocytosis-in-cushing%E2%80%99s-syndrome-persists-post-surgical-remission-and-could-predict-a-lower-remission-prognosis-in-patients-with-cushing%E2%80%99s-disease/

Acute adrenal crisis is a life-threatening state caused by insufficient levels of cortisol, which is a hormone produced and released by the adrenal gland.

Read more at https://cushings.invisionzone.com/topic/56238-call-911-adrenal-crisis-addisonsadrenal-insufficiency/

The success and outcomes of repeat endoscopic transsphenoidal surgery (ETS) for residual or recurrent Cushing's disease (CD) are underreported in the literature. This study aims to address this gap by assessing the safety, feasibility, and efficacy of repeat ETS in these patients.

Read more at https://cushings.invisionzone.com/topic/57729-repeat-endoscopic-endonasal-transsphenoidal-surgery-for-residual-or-recurrent-cushings-disease-safety-feasibility-and-success/

Posterior pituitary tumors (PPTs) are extremely rare, with fewer than 400 cases reported to date. In 2022, the WHO classified four types of tumors originating from the posterior pituitary

Read more at https://cushings.invisionzone.com/topic/57780-oncocytic-pituicytoma-in-a-patient-with-cushings-disease/

Cortisol testing is not routinely done during medical check-ups, and there currently aren’t any at-home tests available to assess cortisol levels. Most healthcare providers only recommend testing for cortisol if there are symptoms indicative of conditions like Cushing’s syndrome.

https://cushings.invisionzone.com/topic/57776-understanding-cortisol-the-stress-hormone-explained/

Paediatric endogenous Cushing syndrome is a rare condition with variable signs and symptoms of presentation. We studied a large cohort of paediatric patients with endogenous Cushing syndrome with the aim of describing anthropometric, clinical, and biochemical characteristics as well as associated complications and outcomes to aid diagnosis, treatment, and management.

Read more at https://cushings.invisionzone.com/topic/57686-paediatric-cushing-syndrome-prospective-multisite-observational-cohort-study/

Endoscopic endonasal surgery is the main transsphenoidal approach for pituitary surgery in many centers, however few studies compare the endoscopic and microscopic surgical approach with regard to long-term follow-up. This single-center study aimed to compare the two techniques over 15 years.

Read more at https://cushings.invisionzone.com/topic/57189-long-term-outcomes-and-complications-from-endoscopic-versus-microscopic-transsphenoidal-surgery-for-cushing%E2%80%99s-disease-%E2%80%93-a-15-year-single-center-study/

Cushing’s syndrome, a clinical condition characterized by hypercortisolemia, exhibits distinct clinical signs and is associated with cyclic cortisol secretion in some patients. The clinical presentation of cyclic Cushing’s syndrome can be ambiguous and its diagnosis is often challenging.

Read more at https://cushings.invisionzone.com/topic/57745-evaluating-the-usefulness-of-plasma-chromogranin-a-measurement-in-cyclic-acth-dependent-cushing%E2%80%99s-syndrome/