The most common cause of Cushing syndrome (CS) is exposure to exogenous glucocorticoids. There is an increasing incidence of adulterated over-the-counter (OTC) supplements containing steroids.

Read more at https://cushings.invisionzone.com/topic/57624-exogenous-cushing-syndrome-and-hip-fracture-due-to-over-the-counter-supplement-artri-king/

The higher IGF-1 index was independently associated with lower prevalence of low bone mass in young CD patients, and IGF-1 might play an important role in the pathogenesis of CD-caused low bone mass.

Read more at https://cushings.invisionzone.com/topic/57619-association-of-igf-1-level-with-low-bone-mass-in-young-patients-with-cushing%E2%80%99s-disease/

Pituitary tumors start in the pituitary gland. They’re usually benign (not cancerous) and rarely spread to other parts of the body. Dr. Borghei-Razavi discusses pituitary tumors and treatments through minimally invasive surgical approaches offered at Cleveland Clinic Florida.

Read more at https://cushings.invisionzone.com/topic/55668-pituitary-tumors-and-treatments/

CHI Memorial Medical Group announces the opening of CHI Memorial Endocrinology Associates, a practice that provides comprehensive medical management and care for conditions like type 1 and 2 diabetes, thyroid disease, thyroid cancer and a range of metabolic, pituitary and adrenal disorders.

The practice will be led by Prashanth Sekhar, MD, a fellowship trained endocrinologist with more than 10 years’ experience helping individuals with hormone-related conditions and diseases.

Read more at https://cushings.invisionzone.com/topic/56496-new-helpful-endo-in-tennessee/

Ectopic Cushing’s syndrome due to metastatic neuroendocrine small-cell carcinoma is a rare condition with a poor prognosis. The options for treatment are few and not necessarily curative. There needs to be increased awareness of this serious and rare complication. Managing the condition can be a challenge and requires a multidisciplinary team approach to improve outcomes.

Read more at https://cushings.invisionzone.com/topic/57577-recurrent-neuroendocrine-tumor-of-the-cervix-presenting-with-ectopic-cushing%E2%80%99s-syndrome/

Cushing’s disease may sometimes make you feel that your life is out of your control. But there are some general things you can do to help take back control.

https://cushings-help.com/2024/11/05/tips-for-living-with-cushings/

Even after pituitary surgery, Cushing's Disease patients faced a higher hazard of complications, especially psychiatric hospitalizations and sepsis.

Read more at https://cushings.invisionzone.com/topic/57746-longterm-outcomes-in-patients-with-cushing%E2%80%99s-disease-vs-non-functioning-pituitary-adenoma-after-pituitary-surgery-an-active-comparator-cohort-study/

Talking about Cushing’s from the spouse/caretaker point of view He is also Monica’s producer/ manager.  For the two years during Monica’s diagnosis and surgeries he worked from home as a computer programmer so that he could take care of Monica. Monica and Kevin were married two years ago, just before Monica’s pituitary surgery...

Read more at https://cushieblogger.com/2019/04/19/archived-interview-monicas-husband-kevin-about-caretakers/

I am thankful, believe it or not, that I had Cushing’s. Mind you, I wouldn’t want to have it now, although diagnoses and surgeries seem “easier” now.

Having Cushing’s taught me a lot, including how to stick up for myself, how to read medical books to learn more about my disease, how to do web design, how to navigate NIH. It taught me patience, how to make phone calls. It brought me a lot of new friends.

Read more at https://www.maryo.co/giving-thanks-day-19-2/

Ferol started noticing irregular symptoms in her late 20’s, but more developed since 2001, and rapidly more chronic as time went by. Finally, at her March 2005 physical, she had enough symptoms listed for her GP to start getting the connection to Cushing’s.

She was immediately referred to Dr. Adam Spitz, endocrinologist, with a battery of tests confirmed the initial diagnosis. Her pituitary surgery was performed 09-30-05. She has lost 30+ pounds after reaching a high of 190 prior to surgery.

Listen at http://www.blogtalkradio.com/cushingshelp/2008/05/08/interview-with-ferolv-pituitary-survivor

Dr. Theodore Friedman (The Wiz) will be giving an updated webinar on how to flourish if you have adrenal insufficiency.

More info at https://cushings.invisionzone.com/topic/57774-webinar-on-how-to-stay-alive-without-adrenals-bla-and-addison%E2%80%99s/

The hormone cortisol is produced by the adrenal glands, so adrenal insufficiency (also called Addison’s disease) is caused when the adrenal glands do not produce cortisol normally. Low cortisol can actually cause anxiety and depression, so some patients may really have anxiety — though doctors need to do further testing and/or evaluation to see that it is caused by their hormone levels, not a mental illness.

https://cushings.invisionzone.com/topic/57767-adrenal-insufficiency-may-be-misdiagnosed-as-anxiety/

The February 2022 issue of Reader's Digest has information about a pituitary Cushing's patient.

Read the article at https://cushings.invisionzone.com/topic/56500-from-this-months-readers-digest/

The new 'pulsatility' therapy, the culmination of ten years' research by the Bristol team, is designed to deliver standard hydrocortisone replacement to patients via a pump which replicates more closely cortisol's natural rhythmic secretion pattern. The pulsatile subcutaneous pump has now revealed promising results in its first clinical trial.

Read more at https://cushings.invisionzone.com/topic/57651-first-of-its-kind-hormone-replacement-treatment-shows-promise-in-patient-trials/

The most common cause of Cushing syndrome (CS) is exposure to exogenous glucocorticoids. There is an increasing incidence of adulterated over-the-counter (OTC) supplements containing steroids.

Read more at https://cushings.invisionzone.com/topic/57624-exogenous-cushing-syndrome-and-hip-fracture-due-to-over-the-counter-supplement-artri-king/

The higher IGF-1 index was independently associated with lower prevalence of low bone mass in young CD patients, and IGF-1 might play an important role in the pathogenesis of CD-caused low bone mass.

Read more at https://cushings.invisionzone.com/topic/57619-association-of-igf-1-level-with-low-bone-mass-in-young-patients-with-cushing%E2%80%99s-disease/

Any condition that causes the adrenal gland to produce excessive cortisol results in the disorder Cushing's syndrome. Cushing syndrome is characterized by facial and torso obesity, high blood pressure, stretch marks on the belly, weakness, osteoporosis, and facial hair growth in females.

Read more at https://cushings.invisionzone.com/topic/56281-basics-cushings-syndrome-vs-cushings-disease/

Ectopic Cushing’s syndrome due to metastatic neuroendocrine small-cell carcinoma is a rare condition with a poor prognosis. The options for treatment are few and not necessarily curative. There needs to be increased awareness of this serious and rare complication. Managing the condition can be a challenge and requires a multidisciplinary team approach to improve outcomes.

Read more at https://cushings.invisionzone.com/topic/57577-recurrent-neuroendocrine-tumor-of-the-cervix-presenting-with-ectopic-cushing%E2%80%99s-syndrome/

Like most everything else in my life, having had Cushing's (pituitary) made this surgery more difficult.  My surgeon had to plan with my endocrinologist how much cortisol I'd need during the operation, then I had to stay overnight to get me successfully weaned off the cortisone again.

Read more at https://cushings.invisionzone.com/topic/57682-what-was-the-most-memorable-thing-that-happened-to-you-last-year/

Development of autoimmune disease was more common in patients with surgical remission of Cushing's disease than in those with surgically treated nonfunctioning pituitary adenomas (NFPAs), according to a retrospective matched cohort study.

Read more at https://www.medpagetoday.com/endocrinology/generalendocrinology/108801?

Cushing’s syndrome is a constellation of features occurring due to high blood cortisol levels. We report a case of a 47-year-old male with a history of recurrent olfactory neuroblastoma (ONB). He presented with bilateral lower limb weakness and anosmia and was found to have Cushing’s syndrome due to high adrenocorticotropic hormone (ACTH) levels from an ectopic source, ONB in this case. Serum cortisol and ACTH levels declined after tumor removal.

Read more at https://cushings.invisionzone.com/topic/57704-olfactory-neuroblastoma-causing-cushing%E2%80%99s-syndrome-due-to-the-ectopic-adrenocorticotropic-hormone-acth-secretion/

Cushing’s disease may sometimes make you feel that your life is out of your control. But there are some general things you can do to help take back control.

https://cushings-help.com/2024/11/05/tips-for-living-with-cushings/

Patients with Cushing syndrome (CS) are at increased risk of venous thromboembolism.

Read more at https://cushings.invisionzone.com/topic/57730-venous-thromboembolism-in-cushing-syndrome/

Pituitary corticotroph adenoma accounts for 68% of endogenous hypercortisolism. Prolonged exposure to high cortisol levels is associated with a variety of long-term complications, impaired quality of life, and increased mortality. Transsphenoidal surgical excision is the treatment of choice. However, curative surgery is challenging with the initial remission rate of 65–85% and a high recurrence rate.

From https://cushings.invisionzone.com/topic/57747-targeted-analysis-of-ubiquitin-specific-peptidase-usp8-in-a-population-of-iranian-people-with-cushing%E2%80%99s-disease-and-a-systematic-review-of-the-literature/

People with Cushing’s syndrome are at an increased risk of developing impaired glucose tolerance and hyperglycemia as a result of increased levels of cortisol throughout the body…

Approximately 10% to 30% of people with Cushing’s syndrome will develop impaired glucose tolerance, while 40% to 45% will develop diabetes.

Read more at https://cushings.invisionzone.com/topic/55671-what-causes-blood-sugar-to-rise-in-non-diabetics/

“My absolute favorite MD. Dr. Maas gets to know her patients and is very thorough. Dr. Maas gave me my life back and I will always love her for that. If you want a great Endocrinologist, she’s your best bet.” – Veronica M.

Read more at https://cushings.invisionzone.com/topic/56235-helpful-doctors-wisconsin/

Patients with Cushing’s syndrome (CS) have an increased venous thromboembolism (VTE) risk with most studies focusing on the perioperative period. The purpose of this study was to assess the 5-year VTE risk and identify predictors of VTE at CS diagnosis.

https://cushings.invisionzone.com/topic/57777-can-we-predict-the-risk-of-venous-thromboembolism-in-patients-with-cushing%E2%80%99s-syndrome/

Bone material properties remain altered in patients with endogenous Cushing's Syndrome, even after long-term remission. These abnormalities, known to be associated with fractures in other populations, may play a role in the persistent bone fragility of steroid excess.

https://cushings.invisionzone.com/topic/57768-bone-material-strength-index-is-low-in-patients-with-cushings-syndrome-even-after-long-term-remission/

The Add Your Bio form has been updated so that it no longer requires Flash. Your information will help others.

I would like to add that if anyone would like to do something for the Cushing's Awareness Challenge but you don't have (or want to have) a blog, why not consider adding your bio to the website this month?

More info at https://cushingsbios.com/2018/08/28/we-have-a-new-bio-form/

We present the case of a 66-year-old female patient who received a referral to endocrinology for an evaluation of obesity due to right knee arthropathy. Taking into consideration her age, she was screened for osteoporosis, with results that showed diminished bone density. Considering this, combined with other clinical features of the patient, suspicion turned toward hypercortisolism. Laboratory findings suggested that the CS was ACTH-dependent and originated in the pituitary gland. 

After a second look at the magnetic resonance imaging results, a 4-mm lesion was identified on the pituitary gland, prompting a transsphenoidal resection of the pituitary adenoma.

Read more at https://cushings.invisionzone.com/topic/57720-from-knee-pain-consultation-to-pituitary-surgery-the-challenge-of-cushing-disease-diagnosis/

Shagufta is a Cushings survivor - post pituitary surgery 20 years ago. Cushing's came back in 2008 after three surgeries. Was put on medication until 2012 when s/he had gamma knife radiotherapy. Still has health issues...

Read more at https://cushings.invisionzone.com/topic/57703-godo1965dar/#comment-478580

This case shows that Cushing’s Syndrome (CS) caused by ectopic corticotropin-releasing hormone (CRH) secretion may masquerade as CS due to a false positive inferior petrosal sinus sampling test (IPSS) test. It also highlights the importance of considering rare causes of CS when diagnostic test results are ambiguous.

Read more at https://cushings.invisionzone.com/topic/57653-ectopic-cushing%E2%80%99s-syndrome-from-a-corticotropin-releasing-hormone-secreting-medullary-thyroid-carcinoma-a-rare-pitfall-af-inferior-petrosal-sinus-sampling/

The most common cause of Cushing syndrome (CS) is exposure to exogenous glucocorticoids. There is an increasing incidence of adulterated over-the-counter (OTC) supplements containing steroids.

Read more at https://cushings.invisionzone.com/topic/57624-exogenous-cushing-syndrome-and-hip-fracture-due-to-over-the-counter-supplement-artri-king/

The higher IGF-1 index was independently associated with lower prevalence of low bone mass in young CD patients, and IGF-1 might play an important role in the pathogenesis of CD-caused low bone mass.

Read more at https://cushings.invisionzone.com/topic/57619-association-of-igf-1-level-with-low-bone-mass-in-young-patients-with-cushing%E2%80%99s-disease/

Ectopic Cushing’s syndrome due to metastatic neuroendocrine small-cell carcinoma is a rare condition with a poor prognosis. The options for treatment are few and not necessarily curative. There needs to be increased awareness of this serious and rare complication. Managing the condition can be a challenge and requires a multidisciplinary team approach to improve outcomes.

Read more at https://cushings.invisionzone.com/topic/57577-recurrent-neuroendocrine-tumor-of-the-cervix-presenting-with-ectopic-cushing%E2%80%99s-syndrome/

Doctors delayed the surgery until he got a CT scan, which did not confirm a lung nodule but did find one on an adrenal gland. Again, doctors postponed surgery to allow for further work-up of the adrenal nodule, which was ultimately found to be benign. The man finally had his hernia repaired after six additional months of debilitating pain and repeated anxiety over incidental test findings suggesting he could have cancer.

From https://www.nytimes.com/2021/11/15/well/live/surgery-medical-tests.html

HOUR-LONG seizures, vision loss in the right eye, and failure to complete sentences are among the challenges that 54-year-old Valrie Anderson has been battling for the last 20 years.

These problems stem from a condition called pituitary adenoma, which is a growth or tumour on the pituitary gland in the brain.

Read more at https://cushingsbios.com/2022/03/21/valrie-pituitary-news-item/

Cushing’s disease may sometimes make you feel that your life is out of your control. But there are some general things you can do to help take back control.

https://cushings-help.com/2024/11/05/tips-for-living-with-cushings/

Headaches are a common complaint in patients with pituitary tumors. Although many patients presumably have headaches which are unrelated to their pituitary tumor, there are several important direct and indirect mechanisms by which pituitary tumors may elicit or exacerbate headaches. Pituitary tumors may directly provoke headaches by eroding laterally into the cavernous sinus, which contains the first and second divisions of the trigeminal nerve, by involvement of the dural lining of the sella or diaphragma sella (which are innervated by the trigeminal nerve), or via sinusitis, particularly after transsphenoidal surgery. 

Read more at https://cushings.invisionzone.com/topic/56287-pituitary-tumors-and-headaches/

Ectopic co-secretion of corticotropin-releasing hormone (CRH) and adrenocorticotropic hormone (ACTH) in silent (i.e., noncatecholamine-secreting) pheochromocytoma is a rare cause of Cushing Syndrome (CS).

Read more at https://cushings.invisionzone.com/topic/57695-cushing-syndrome-due-to-a-crh-and-acth-secreting-silent-pheochromocytoma/

Cushing syndrome is a metabolic disease caused by chronic exposure to high levels of glucocorticoids. It can present as an endocrine emergency due to a rapid increase in circulating cortisol leading to increased risk of cardiovascular disease and infection. Etomidate rapidly reduces plasma cortisol levels by inhibiting the action of 11β-hidroxilase. We report the case of a patient with severe hypercortisolaemia accompanied by metabolic and psychiatric disorders in whom administration of etomidate reduced preoperative levels of cortisol.

Read more at https://cushings.invisionzone.com/topic/57636-etomidate-in-the-treatment-of-cushing-syndrome/

The most common cause of Cushing syndrome (CS) is exposure to exogenous glucocorticoids. There is an increasing incidence of adulterated over-the-counter (OTC) supplements containing steroids.

Read more at https://cushings.invisionzone.com/topic/57624-exogenous-cushing-syndrome-and-hip-fracture-due-to-over-the-counter-supplement-artri-king/

The higher IGF-1 index was independently associated with lower prevalence of low bone mass in young CD patients, and IGF-1 might play an important role in the pathogenesis of CD-caused low bone mass.

Read more at https://cushings.invisionzone.com/topic/57619-association-of-igf-1-level-with-low-bone-mass-in-young-patients-with-cushing%E2%80%99s-disease/

The diagnosis of Cushing's Syndrome is a three-step process that includes its suspicion based on the patient's laboratory and semiologic findings, the documentation of hypercortisolism, and the identification of its cause, which can be either ACTH-dependent or independent.

Read more at https://cushings.invisionzone.com/topic/57668-adrenocorticotropin-dependent-ectopic-cushings-syndrome-a-case-report/

Ectopic Cushing’s syndrome due to metastatic neuroendocrine small-cell carcinoma is a rare condition with a poor prognosis. The options for treatment are few and not necessarily curative. There needs to be increased awareness of this serious and rare complication. Managing the condition can be a challenge and requires a multidisciplinary team approach to improve outcomes.

Read more at https://cushings.invisionzone.com/topic/57577-recurrent-neuroendocrine-tumor-of-the-cervix-presenting-with-ectopic-cushing%E2%80%99s-syndrome/

The first injection of Insulin ( called isletin originally ) on Leonard Thompson, a 14-year-old diabetic who lay dying at the Toronto General Hospital on January 11, 1922 caused a severe allergic reaction.

For the next 12 days the biochemist James Collip worked to improve and purify the ox-pancreas extract and on the second injection bought the boy out of his coma and was a complete success.

More about History of Insulin

The diagnostic performance of hrMRI was higher than cMRI and dMRI for identifying pituitary microadenomas in Cushing’s syndrome.

About 80% of patients, who were misdiagnosed on cMRI and dMRI, were correctly diagnosed on hrMRI.

Read more at https://cushings.invisionzone.com/topic/57618-high-resolution-contrast-enhanced-mri-with-three-dimensional-fast-spin-echo-improved-the-diagnostic-performance-for-identifying-pituitary-microadenomas-in-cushing%E2%80%99s-syndrome/

Cushing’s disease may sometimes make you feel that your life is out of your control. But there are some general things you can do to help take back control.

https://cushings-help.com/2024/11/05/tips-for-living-with-cushings/

This case report presents an unusual manifestation of CS in a 48-year-old male with a history of hypertension, where severe hypokalemia was the primary presentation.

Read more at https://cushings.invisionzone.com/topic/57721-unveiling-the-uncommon-cushing%E2%80%99s-syndrome-cs-masquerading-as-severe-hypokalemia/

Endogenous Cushing's Syndrome is associated with increased risk for glaucoma regardless of remission status and develops at a younger age compared with the general population.

https://cushings.invisionzone.com/topic/57769-higher-risk-and-earlier-onset-glaucoma-in-cushings-syndrome/

Cushing’s disease is a rare neuroendocrine disorder with excessive endogenous cortisol, impaired cognition, and psychiatric symptoms. Evidence from resting-state fMRI revealed the abnormalities of static brain connectivity in patients with Cushing’s disease (CD patients). 

Read more at https://cushings.invisionzone.com/topic/57655-dynamic-functional-connectivity-changes-associated-with-psychiatric-traits-and-cognitive-deficits-in-cushing%E2%80%99s-disease/

The most common cause of Cushing syndrome (CS) is exposure to exogenous glucocorticoids. There is an increasing incidence of adulterated over-the-counter (OTC) supplements containing steroids.

Read more at https://cushings.invisionzone.com/topic/57624-exogenous-cushing-syndrome-and-hip-fracture-due-to-over-the-counter-supplement-artri-king/

The higher IGF-1 index was independently associated with lower prevalence of low bone mass in young CD patients, and IGF-1 might play an important role in the pathogenesis of CD-caused low bone mass.

Read more at https://cushings.invisionzone.com/topic/57619-association-of-igf-1-level-with-low-bone-mass-in-young-patients-with-cushing%E2%80%99s-disease/

Ectopic Cushing’s syndrome due to metastatic neuroendocrine small-cell carcinoma is a rare condition with a poor prognosis. The options for treatment are few and not necessarily curative. There needs to be increased awareness of this serious and rare complication. Managing the condition can be a challenge and requires a multidisciplinary team approach to improve outcomes.

Read more at https://cushings.invisionzone.com/topic/57577-recurrent-neuroendocrine-tumor-of-the-cervix-presenting-with-ectopic-cushing%E2%80%99s-syndrome/

Postoperative data on Cushing’s disease (CD) are equivocal in the literature. These discrepancies may be attributed to different series with different criteria for remission and variable follow-up durations. Additional data from experienced centers may address these discrepancies. In this study, we present the results obtained from 96 endoscopic transsphenoidal surgeries (ETSSs) for CD conducted in a well-experienced center.

Read more at https://cushings.invisionzone.com/topic/57706-medium-and-long-term-data-from-a-series-of-96-endoscopic-transsphenoidal-surgeries-for-cushing-disease/

Patients with Cushing’s disease (CD) face challenges living with and receiving appropriate care for this rare, chronic condition. Even with successful treatment, many patients experience ongoing symptoms and impaired quality of life (QoL). Different perspectives and expectations between patients and healthcare providers (HCPs) may also impair well-being.

Read more at https://cushings.invisionzone.com/topic/57696-different-patient-versus-provider-perspectives-on-living-with-cushing%E2%80%99s-disease/

Cushing’s disease may sometimes make you feel that your life is out of your control. But there are some general things you can do to help take back control.

https://cushings-help.com/2024/11/05/tips-for-living-with-cushings/

Currently, magnetic resonance imaging (MRI) is the gold standard for detecting pituitary adenomas. Nevertheless, modern MRI modalities, including dynamic or volumetric sequences, can reliably detect corticotrophic adenomas in 50–90% cases of CD [9,10,11,12]. This indicates that complementary imaging strategies are required to improve the localization of primary lesions in CD.

Read more at https://cushings.invisionzone.com/topic/57637-dexamethasone-suppression-for%C2%A018f-fdg-petct-to-localize-acth-secreting-pituitary-tumors/

Adding a corticotropin-releasing hormone (CRH) stimulation test immediately following a 2-day low-dose dexamethasone suppression test (LDDST) ― what's known as a Dex-CRH test and was first introduced in 1993 ― identified Cushing disease in 5 of 65 people (7.7%) with a confirmed diagnosis but who had previously shown normal cortisol levels on a conventional LDDST.

Read more at https://cushings.invisionzone.com/topic/57586-crh-stimulation-test-boosts-cushing-disease-diagnosis/

Limited data suggest that the rate of correct IPSS tumor lateralization may not be positively associated with postoperative remission or cure in patients with Cushing’s disease. These findings bring into question the utility of IPSS tumor lateralization in the context of preoperative planning and surgical approach rather than confirming a pituitary source.

Read more at https://cushings.invisionzone.com/topic/57675-inferior-petrosal-sinus-sampling-ipss-tumor-lateralization-and-the-surgical-treatment-of-cushing%E2%80%99s-disease/

• Among women who underwent pituitary surgery to treat Cushing disease subsequent pregnancy had no apparent effect on Cushing disease recurrence, in a single-center review of 113 women treated over a 30-year period.

Read more at https://cushings.invisionzone.com/topic/56702-pregnancy-doesnt-boost-cushing-disease-recurrences/

Early diagnosis and immediate treatment of Cushing’s syndrome (CS) are critical for a better prognosis but remain a challenge. However, few comprehensive reports have focused on this issue or investigated whether patient-reported manifestations are consistent with physician-assessed symptoms of CS. This study aimed to clarify the differences in patient-reported and physician-assessed manifestations of signs and symptoms of CS that prevent early diagnosis.

Read more at https://cushings.invisionzone.com/topic/57749-diagnostic-dilemma-in-cushing%E2%80%99s-syndrome-discrepancy-between-patient-reported-and-physician-assessed-manifestations/

Schumer revealed she has exogenous Cushing syndrome, brought on by getting steroid injections that resulted in excess cortisol in her body. According to the Mayo Clinic, the condition can lead to weight gain, fatigue, “moon face,” headaches and other symptoms.

Read more at https://cushingsbios.com/2024/02/24/amy-schumer-steroid-induced-cushings/

The most common cause of Cushing syndrome (CS) is exposure to exogenous glucocorticoids. There is an increasing incidence of adulterated over-the-counter (OTC) supplements containing steroids.

Read more at https://cushings.invisionzone.com/topic/57624-exogenous-cushing-syndrome-and-hip-fracture-due-to-over-the-counter-supplement-artri-king/

The higher IGF-1 index was independently associated with lower prevalence of low bone mass in young CD patients, and IGF-1 might play an important role in the pathogenesis of CD-caused low bone mass.

Read more at https://cushings.invisionzone.com/topic/57619-association-of-igf-1-level-with-low-bone-mass-in-young-patients-with-cushing%E2%80%99s-disease/

The first-line treatment for Cushing’s disease is transsphenoidal surgery, after which the rates of remission are 60 to 80%, with long-term recurrence of 20 to 30%, even in those with real initial remission. Drug therapies are indicated for patients without initial remission or with surgical contraindications or recurrence, and ketoconazole is one of the main available therapies.

Read more at https://cushings.invisionzone.com/topic/57574-evaluation-of-ketoconazole-as-a-treatment-for-cushing%E2%80%99s-disease-in-a-retrospective-cohort/

Ectopic Cushing’s syndrome due to metastatic neuroendocrine small-cell carcinoma is a rare condition with a poor prognosis. The options for treatment are few and not necessarily curative. There needs to be increased awareness of this serious and rare complication. Managing the condition can be a challenge and requires a multidisciplinary team approach to improve outcomes.

Read more at https://cushings.invisionzone.com/topic/57577-recurrent-neuroendocrine-tumor-of-the-cervix-presenting-with-ectopic-cushing%E2%80%99s-syndrome/

The differential diagnosis between Cushing’s disease (CD) and ectopic ACTH syndrome (EAS) is complex, and bilateral inferior petrosal sinus sampling (BIPSS) is considered the gold-standard test. However, BIPSS with corticotropin-releasing hormone (CRH) stimulation is rarely available.

Read more at https://cushings.invisionzone.com/topic/57629-enhancing-cushing%E2%80%99s-disease-diagnosis-exploring-the-impact-of-desmopressin-on-acth-gradient-during-bipss/

Patients suffering from acromegaly and Cushing’s Disease (CD) face the risk of several clinical complications. The onset of diabetes mellitus (DM) is among the most important: exposure to elevated growth hormone or cortisol levels is associated with insulin resistance (IR).

Read more at https://cushings.invisionzone.com/topic/57750-management-of-diabetes-mellitus-in-acromegaly-and-cushing%E2%80%99s-disease-with-focus-on-pasireotide-therapy/

Fact:  However, in the case of the chronically ill, a different cycle occurs. In the chronically ill, the person loses his normal health. He goes through a period of treatment and sometimes recovers...

Read more at https://cushieblogger.com/2022/04/27/myth-you-should-be-all-better-by-now-2/

Hi my name is Shagufta and I have had Cushings Disease for over 16 years ..Post surgery and still suffering since surgery in 2004/2005.. I was diagnosed in 2004 after suffering and running back and forth to the doctors for over 10 years .. I think my symptoms started in 1990 when I had an early menopause at 24 years old.. I had benign tumour in the Pitituary gland .. Had Pitituary surgery 3 times 2004/2005 before it was successful..

Read more at https://cushieblogger.com/2022/04/24/myth-after-a-cure-for-cushings-everyone-heals-and-goes-back-to-normal-2/

The association between empty sella turcica (EST) syndrome and Cushing's disease has been rarely reported. It is plausible to hypothesize that EST syndrome in association with Cushing's disease can be attributed to intracranial hypertension

Read more at https://cushings.invisionzone.com/topic/57609-cushings-disease-associated-with-partially-empty-sella-turcica-syndrome/

Cushing’s disease may sometimes make you feel that your life is out of your control. But there are some general things you can do to help take back control.

https://cushings-help.com/2024/11/05/tips-for-living-with-cushings/

The most common procedure to remove pituitary tumors is transsphenoidal adenomectomy. It allows the removal of the tumor with minimal damage to the surrounding structures. The surgical team accesses the pituitary gland through the sphenoid sinus — a hollow space behind the nasal passages and below the pituitary gland.

Read more at https://cushings.invisionzone.com/topic/57620-basics-treatment-transsphenoidal-adenomectomy/

The success and outcomes of repeat endoscopic transsphenoidal surgery (ETS) for residual or recurrent Cushing’s disease (CD) are underreported in the literature. This study aims to address this gap by assessing the safety, feasibility, and efficacy of repeat ETS in these patients.

Read more at https://cushings.invisionzone.com/topic/57731-repeat-endoscopic-endonasal-transsphenoidal-surgery-for-residual-or-recurrent-cushing%E2%80%99s-disease-safety-feasibility-and-success/

After your physicians have determined that it is reasonably safe to discharge you from the hospital following transsphenoidal pituitary surgery there are a number of important situations that may arise. Most people feel well after discharge. However, you should be aware of these possible problems, just in case. The following general guidelines are provided to promote your health and safety.

Headache, facial, and sinus pain are not uncommon following pituitary surgery. As you may have noted, the pain and discomfort typically improve on a daily basis following surgery. If you should experience a worsening of your pain or discomfort, please contact your neurosurgeon immediately.

Read more at http://www.cushings-info.com/index.php?title=Pituitary_Post-Op

Patients with suspected adrenocortical carcinoma (ACC) may also undergo additional tests to identify excess sex steroids and steroid precursors, mineralocorticoids and glucocorticoids.

Read more at https://cushings.invisionzone.com/topic/57561-basics-diagnostic-procedures-in-suspected-adrenocortical-carcinoma/

The most common cause of Cushing syndrome (CS) is exposure to exogenous glucocorticoids. There is an increasing incidence of adulterated over-the-counter (OTC) supplements containing steroids.

Read more at https://cushings.invisionzone.com/topic/57624-exogenous-cushing-syndrome-and-hip-fracture-due-to-over-the-counter-supplement-artri-king/

The higher IGF-1 index was independently associated with lower prevalence of low bone mass in young CD patients, and IGF-1 might play an important role in the pathogenesis of CD-caused low bone mass.

Read more at https://cushings.invisionzone.com/topic/57619-association-of-igf-1-level-with-low-bone-mass-in-young-patients-with-cushing%E2%80%99s-disease/

Sixty-nine endocrinologists abstracted data from 273 unique medical charts of patients with CS. Mean patient age was 46.5 ± 13.4 years, with a 60:40 (female:male) gender split. The mean duration of endogenous CS amongst patients was 4.1 years. Chart data indicated that patients experienced a high burden of comorbidities and symptoms, including fatigue, weight gain, and muscle weakness despite multi-modal treatment. 

Read more at https://cushings.invisionzone.com/topic/57687-a-medical-chart-audit-to-assess-endocrinologist-perceptions-of-the-burden-of-endogenous-cushing%E2%80%99s-syndrome/

Kate (Fairley), July 17, 2008. Kate had symptoms since 1991. She had two pituitary surgeries and another recurrence. She is not yet cured and her current diagnoses are Idiopathic Intracranial Hypertension, panhypopituitarism and a CSF leak. She has appeared on National Geographic TV in the Science of Obesity.

Listen at https://cushieblogger.com/2019/04/29/archived-interview-kate-fairley/

Sadly, Kate was only 46 when she died on June 23, 2014.  Her bio and video can be found here: https://cushingsbios.com/2015/06/23/1623/

Jenni was a 26-year-old who had complications from two unsuccessful operations to remove a tumor of the pituitary gland.

A Type 2 diabetic since 2002, Miss Moore suffered from emotionally unstable personality disorder and an abusive relationship, before a diagnosis of Cushing's disease as a result of the tumor.

Read more at https://cushingsbios.com/2022/01/25/in-memory-jenni-moore-january-25-2016/

Ectopic Cushing’s syndrome due to metastatic neuroendocrine small-cell carcinoma is a rare condition with a poor prognosis. The options for treatment are few and not necessarily curative. There needs to be increased awareness of this serious and rare complication. Managing the condition can be a challenge and requires a multidisciplinary team approach to improve outcomes.

Read more at https://cushings.invisionzone.com/topic/57577-recurrent-neuroendocrine-tumor-of-the-cervix-presenting-with-ectopic-cushing%E2%80%99s-syndrome/

Like most everything else in my life, having had Cushing's (pituitary) made this surgery more difficult.  My surgeon had to plan with my endocrinologist how much cortisol I'd need during the operation, then I had to stay overnight to get me successfully weaned off the cortisone again.

Read more at https://cushings.invisionzone.com/topic/57682-what-was-the-most-memorable-thing-that-happened-to-you-last-year/

I do also seem to have GIP dependent Cushing and I was wondering if there was any enlargement of your adrenals visible in imaging, cause mine are small which confuses all my endocrinologists and surgeons. Thank you the most!

Read more at https://cushingsbios.com/2013/06/23/magdalena-food-dependent-cushings-bio/

The diagnosis of Cushing’s syndrome is challenging; however, through the clinical picture and the search for secondary causes of osteoporosis, it was possible to reach the diagnosis of the case reported. There was an independent, symptomatic ACTH hypercortisolism manifested by typical phenotypic changes, severe secondary osteoporosis and arterial hypertension in a young patient.

Read more at https://cushings.invisionzone.com/topic/57610-severe-osteoporosis-in-a-young-man-with-bilateral-cushing%E2%80%99s-syndrome/

Cushing’s disease may sometimes make you feel that your life is out of your control. But there are some general things you can do to help take back control.

https://cushings-help.com/2024/11/05/tips-for-living-with-cushings/

Acute adrenal crisis is a life-threatening state caused by insufficient levels of cortisol, which is a hormone produced and released by the adrenal gland.

Read more at https://cushings.invisionzone.com/topic/56238-call-911-adrenal-crisis-addisonsadrenal-insufficiency/

Well, I'm 29 now and still undiagnosed. If Cushing's is what's wrong with me, I have had it for quite a long time. I gained a lot of weight (60 lbs) the last 2 years of high school (17-18 years old). I lost 30 lbs at age 19 (I just didn't eat much) and have since gained 70 lbs.

Read more at https://cushingsbios.com/2022/03/26/dana-undiagnosed-bio/

At NIH I set up a daily “routine” of sorts and listening to these tapes was a very important part of my day and helped me get through the ordeal of more testing, surgery, post-op and more.

When I had my kidney cancer surgery, those tapes were long broken and irreplaceable, but I had replaced all the songs – this time on my iPod.

Read more at https://cushings.invisionzone.com/topic/56885-day-25-cushing%E2%80%99s-awareness-challenge-2022/

Dr. Dori Middleman is a Psychophamacologist, Certified Gestalt Psychotherapist and Cushing’s Patient.

She has had both pituitary surgery and two gamma knife radiosurgeries.

Listen at  https://cushieblogger.com/2019/04/25/archived-interview-dr-dori-middleman-pituitary-cushings-survivor/

Donna Sellers, President, John’s Foundation for Cushing’s Awareness, mother of a Cushing’s patient.

Listen at http://www.blogtalkradio.com/cushingshelp/2008/06/19/interview-with-donna-sellers-mother-of-a-cushings-patient