“In general, cortisol levels tend to peak in the late morning and gradually decline throughout the day,” he explains. “When a stressful event occurs, the increased cortisol will work alongside our ‘fight or flight’ mechanisms to either upregulate or downregulate bodily functions. [Affected systems include] the central nervous system, cardiovascular system, gastrointestinal system, or immune system.”

Read more at https://cushings.invisionzone.com/topic/57552-basics-what-causes-abnormal-cortisol-levels/

The most common cause of Cushing syndrome (CS) is exposure to exogenous glucocorticoids. There is an increasing incidence of adulterated over-the-counter (OTC) supplements containing steroids.

Read more at https://cushings.invisionzone.com/topic/57624-exogenous-cushing-syndrome-and-hip-fracture-due-to-over-the-counter-supplement-artri-king/

Patients with neuroendocrine tumors before ectopic Cushing syndrome development were more likely metastatic and had worse survival

Read more at https://cushings.invisionzone.com/topic/56894-management-of-adrenocorticotropic-hormone-secreting-neuroendocrine-tumors-and-the-role-of-bilateral-adrenalectomy-in-ectopic-cushing-syndrome/

The higher IGF-1 index was independently associated with lower prevalence of low bone mass in young CD patients, and IGF-1 might play an important role in the pathogenesis of CD-caused low bone mass.

Read more at https://cushings.invisionzone.com/topic/57619-association-of-igf-1-level-with-low-bone-mass-in-young-patients-with-cushing%E2%80%99s-disease/

Ectopic Cushing’s syndrome due to metastatic neuroendocrine small-cell carcinoma is a rare condition with a poor prognosis. The options for treatment are few and not necessarily curative. There needs to be increased awareness of this serious and rare complication. Managing the condition can be a challenge and requires a multidisciplinary team approach to improve outcomes.

Read more at https://cushings.invisionzone.com/topic/57577-recurrent-neuroendocrine-tumor-of-the-cervix-presenting-with-ectopic-cushing%E2%80%99s-syndrome/

Key takeaways:

• Cushing’s syndrome symptoms moderately impact quality of life for adults with the condition.
• Weight gain, muscle fatigue and menstrual changes decline in severity from diagnosis to follow-up.

Read more at https://cushings.invisionzone.com/topic/57630-adults-with-cushing%E2%80%99s-syndrome-report-high-burden-of-illness-despite-ongoing-treatment/

This is a randomized, placebo-controlled, crossover study of SPI-62 in subjects with ACTH-dependent Cushing's syndrome. Subjects will receive each of the following 2 treatments for 12 weeks: SPI-62 and matching placebo

Read more at https://cushings.invisionzone.com/topic/57566-clinical-trial-spi-62-as-a-treatment-for-adrenocorticotropic-hormone-dependent-cushings-syndrome-rescue/

Surgery beyond the age of 75, mainly relying on an endoscopic endonasal transsellar approach, is effective and safe, provided that patients are managed in tertiary centers.

Read more at https://cushings.invisionzone.com/topic/57640-pituitary-surgery-outcome-in-patients-75%C2%A0years-and-older/

Has your doctor ever tried to dissuade you from using an alternative treatment?

Read more at https://cushings.invisionzone.com/topic/57567-what-do-you-think-alternative-treatments/

Lenise passed away Wednesday, Oct. 2, 2002 at 23 years old, just after her surgery.

Read more at https://cushingsbios.com/2021/10/02/in-memory-of-lenise-petersen-october-2-2002-3/

Patients with Cushing’s disease (CD) experienced transient central adrenal insufficiency (CAI) after successful surgery. However, the reported recovery time of hypothalamic-pituitary-adrenal (HPA) axis varied and the risk factors which could affect recovery time of HPA axis had not been extensively studied. This study aimed to analyze the duration of CAI and explore the risk factors affecting HPA axis recovery in post-operative CD patients with biochemical remission.

Read more at https://cushings.invisionzone.com/topic/57581-preop-tt3-predicts-hpa-axis-recovery-after-cushing-surgery/

The most common cause of Cushing syndrome (CS) is exposure to exogenous glucocorticoids. There is an increasing incidence of adulterated over-the-counter (OTC) supplements containing steroids.

Read more at https://cushings.invisionzone.com/topic/57624-exogenous-cushing-syndrome-and-hip-fracture-due-to-over-the-counter-supplement-artri-king/

Patients with neuroendocrine tumors before ectopic Cushing syndrome development were more likely metastatic and had worse survival

Read more at https://cushings.invisionzone.com/topic/56894-management-of-adrenocorticotropic-hormone-secreting-neuroendocrine-tumors-and-the-role-of-bilateral-adrenalectomy-in-ectopic-cushing-syndrome/

The higher IGF-1 index was independently associated with lower prevalence of low bone mass in young CD patients, and IGF-1 might play an important role in the pathogenesis of CD-caused low bone mass.

Read more at https://cushings.invisionzone.com/topic/57619-association-of-igf-1-level-with-low-bone-mass-in-young-patients-with-cushing%E2%80%99s-disease/

Ectopic Cushing’s syndrome due to metastatic neuroendocrine small-cell carcinoma is a rare condition with a poor prognosis. The options for treatment are few and not necessarily curative. There needs to be increased awareness of this serious and rare complication. Managing the condition can be a challenge and requires a multidisciplinary team approach to improve outcomes.

Read more at https://cushings.invisionzone.com/topic/57577-recurrent-neuroendocrine-tumor-of-the-cervix-presenting-with-ectopic-cushing%E2%80%99s-syndrome/

Endocrinologic evaluation revealed grossly elevated 24-hour urinary free cortisol and elevated serum cortisol levels consistent with severe Cushing’s syndrome, and she was started on high-dose ketoconazole.

Read more at https://cushings.invisionzone.com/topic/57592-an-aggressive-case-of-adrenocortical-carcinoma-complicated-by-paraneoplastic-cushing%E2%80%99s-syndrome/

The founder of Adrenal Alternatives Foundation has suffered a severe adrenal crisis yesterday morning. She is alive but fighting for her life.
We are unsure of the status of the Foundation at this time.

This is the unfortunate reality of this disease, not even the strongest ones are exempt from the toll it takes. Keep fighting, adrenal warriors.

Read more at https://cushings.invisionzone.com/topic/57593-please-pray-for-the-founder-of-the-adrenal-alternatives-foundation/

...Being constantly diagnosed as “healthy” caused me to be told, when I was finally diagnosed correctly, that I had maybe five years to live. Misdiagnosis can be a killer.… It is now my personal mission and obligation to help those suffering from any chronic illness that steals your joy, and bring awareness to Endocrine Disorders. From my journey through Cushing’s to Addison’s to recovery—from triathlete to barely being able to dress myself and finally to recovering into a stronger person I never knew I was.

Read more at https://amzn.to/2pWMhOh

In Cushing’s syndrome (CS), chronic glucocorticoid excess (GC) and disrupted circadian rhythm lead to insulin resistance (IR), diabetes mellitus, dyslipidaemia and cardiovascular comorbidities. As undifferentiated, self-renewing progenitors of adipocytes, mesenchymal stem cells (MSCs) may display the detrimental effects of excess GC, thus revealing a promising model to study the molecular mechanisms underlying the metabolic complications of CS.

Read more at https://cushings.invisionzone.com/topic/56741-a-promising-in-vitro-model-to-study-cushing%E2%80%99s-syndrome/

This breaks my heart. Liz was so young. She was finally so hopeful after way too long. We have to do something to change this. People especially doctors have to know what we go through. Mary is one person and look at all she has done to raise awareness. We are so many. There has to be something we all can do. 

Read more at https://cushingsbios.com/2021/03/01/in-memory-liz-raftery-march-2012/

The Add Your Bio form has been updated so that it no longer requires Flash. Your information will help others.

I would like to add that if anyone would like to do something for the Cushing's Awareness Challenge but you don't have (or want to have) a blog, why not consider adding your bio to the website this month?

More info at https://cushingsbios.com/2018/08/28/we-have-a-new-bio-form/

Thursday, October 3, 2002

Alice died of lung cancer and Cushing’s.

Read more at https://cushingsbios.com/2021/10/03/in-memory-alice-baker-october-3-2002/

Evaluate whether age-related differences exist in clinical characteristics, diagnostic approach and management strategies in patients with Cushing’s syndrome included in the European Registry on Cushing’s Syndrome (ERCUSYN).

Read more at https://cushings.invisionzone.com/topic/57599-cushing%E2%80%99s-syndrome-in-the-elderly-data-from-the-european-registry-on-cushing%E2%80%99s-syndrome/

The most common cause of Cushing syndrome (CS) is exposure to exogenous glucocorticoids. There is an increasing incidence of adulterated over-the-counter (OTC) supplements containing steroids.

Read more at https://cushings.invisionzone.com/topic/57624-exogenous-cushing-syndrome-and-hip-fracture-due-to-over-the-counter-supplement-artri-king/

Patients with neuroendocrine tumors before ectopic Cushing syndrome development were more likely metastatic and had worse survival

Read more at https://cushings.invisionzone.com/topic/56894-management-of-adrenocorticotropic-hormone-secreting-neuroendocrine-tumors-and-the-role-of-bilateral-adrenalectomy-in-ectopic-cushing-syndrome/

The higher IGF-1 index was independently associated with lower prevalence of low bone mass in young CD patients, and IGF-1 might play an important role in the pathogenesis of CD-caused low bone mass.

Read more at https://cushings.invisionzone.com/topic/57619-association-of-igf-1-level-with-low-bone-mass-in-young-patients-with-cushing%E2%80%99s-disease/

Dr. Karen Thames shared these on her Facebook Page, Empowering People with Invisible Chronic Illness – The EPIC Foundation

She has graciously given me permission to share them here and in the CushieWiki and on the Cushing’s Help message boards.

Read more at https://cushieblogger.com/2022/04/03/cushings-myths-and-facts-4/

Ectopic Cushing’s syndrome due to metastatic neuroendocrine small-cell carcinoma is a rare condition with a poor prognosis. The options for treatment are few and not necessarily curative. There needs to be increased awareness of this serious and rare complication. Managing the condition can be a challenge and requires a multidisciplinary team approach to improve outcomes.

Read more at https://cushings.invisionzone.com/topic/57577-recurrent-neuroendocrine-tumor-of-the-cervix-presenting-with-ectopic-cushing%E2%80%99s-syndrome/

Through the newly available dial-up internet, I joined forces with a small group of wonderful Cushing’s advocates. Cathy Gifford and Mary O’Connor, were my first Cushing’s friends, and are still dear friends twenty one years later. Together we got things moving. Mary, has built the largest Cushing’s support boards, and her admirable dedication continues to help and support patients from all over the world, Cushing’s Help and Support (cushings-help.com).

Read more at https://cushieblogger.com/2022/04/03/kind-words-for-cushings-awareness-month/

Please consider joining us for #Pituitary Tumor Support Group on Saturday October 7th, 2023 at 9am to discuss Current and Emerging Medical Therapies in Pituitary Tumor Treatment by Dr. Mahalakshi Honasage, #Endocrinologist, and Dr. Jack Rock, #Neurosurgery.

More information at https://cushings.invisionzone.com/topic/57635-pituitary%C2%A0tumor-support-group/#comment-478468

Sharmyn McGraw searched for answers for seven years for whatever it was that was killing her; finally she diagnosed herself via the Internet with Cushing’s disease, caused by a pituitary brain tumor. 

See the video at https://cushieblogger.com/2019/04/03/video-cushings-disease-pituitary-gland/

One of my least favorite things about my life with chronic illness is having imaging appointments.  Whether it's my yearly brain MRI, or a chest X-ray, the whole process is uncomfortable, and sometimes even painful...

Read more at https://cushieblogger.com/2019/04/03/from-a-past-blogging-challenge-cushings-awareness-challenge-danielle-day-3/

Interview with Judy, the mother of two Cushing’s patients, and her daughter, Jess, a high school student with Cushing’s. Robin (staticnrg) hosted.

Read more at https://cushieblogger.com/2022/04/11/archived-interview-with-judy-mom-to-two-cushings-patients-and-her-daughter-jess-3/

The most common cause of Cushing syndrome (CS) is exposure to exogenous glucocorticoids. There is an increasing incidence of adulterated over-the-counter (OTC) supplements containing steroids.

Read more at https://cushings.invisionzone.com/topic/57624-exogenous-cushing-syndrome-and-hip-fracture-due-to-over-the-counter-supplement-artri-king/

Patients with neuroendocrine tumors before ectopic Cushing syndrome development were more likely metastatic and had worse survival

Read more at https://cushings.invisionzone.com/topic/56894-management-of-adrenocorticotropic-hormone-secreting-neuroendocrine-tumors-and-the-role-of-bilateral-adrenalectomy-in-ectopic-cushing-syndrome/

The higher IGF-1 index was independently associated with lower prevalence of low bone mass in young CD patients, and IGF-1 might play an important role in the pathogenesis of CD-caused low bone mass.

Read more at https://cushings.invisionzone.com/topic/57619-association-of-igf-1-level-with-low-bone-mass-in-young-patients-with-cushing%E2%80%99s-disease/

Ectopic Cushing’s syndrome due to metastatic neuroendocrine small-cell carcinoma is a rare condition with a poor prognosis. The options for treatment are few and not necessarily curative. There needs to be increased awareness of this serious and rare complication. Managing the condition can be a challenge and requires a multidisciplinary team approach to improve outcomes.

Read more at https://cushings.invisionzone.com/topic/57577-recurrent-neuroendocrine-tumor-of-the-cervix-presenting-with-ectopic-cushing%E2%80%99s-syndrome/

“The pituitary is commonly referred to as the ‘master’ gland because it does so many important jobs in the body,” says Karen Frankwich, MD, a board-certified endocrinologist at Mission Hospital. “Not only does the pituitary make its own hormones, but it also triggers hormone production in other glands. The pituitary is aided in its job by the hypothalamus. This part of the brain is situated above the pituitary, and sends messages to the gland on when to release or stimulate production of necessary hormones.”

Read more at https://cushings.invisionzone.com/topic/56334-the-pituitary-gland-small-but-mighty/

Read more at https://cushings.invisionzone.com/topic/57594-complete-and-sustained-remission-of-hypercortisolism-with-pasireotide-treatment-of-an-adrenocorticotropic-hormone-acth-secreting-thoracic-neuroendocrine-tumour-an-n-of-1-trial/

%MCEPASTEBIN%

Stress-related brain disorders can be associated with glucocorticoid disturbance and hippocampal alteration. However, it remains largely unknown how cortisol affects the structure and function of hippocampus. Cushing's disease (CD) provides a unique “hyperexpression model” to explore the effects of excessive cortisol on hippocampus as well as the relation between these effects and neuropsychological deficits.

Read more at https://cushings.invisionzone.com/topic/56924-altered-hippocampal-volume-and-functional-connectivity-in-patients-with-cushings-disease/

Cushing’s disease (CD) is a serious endocrine disorder caused by an adrenocorticotropic hormone (ACTH)-secreting pituitary neuroendocrine tumor (PitNET) that stimulates the adrenal glands to overproduce cortisol. Chronic exposure to excess cortisol has detrimental effects on health, including increased stroke rates, diabetes, obesity, cognitive impairment, anxiety, depression, and death. The first-line treatment for CD is pituitary surgery. Current surgical remission rates reported in only 56% of patients depending on several criteria. The lack of specificity, poor tolerability, and low efficacy of the subsequent second-line medical therapies make CD a medical therapeutic challenge. One major limitation that hinders the development of specific medical therapies is the lack of relevant human model systems that recapitulate the cellular composition of PitNET microenvironment.

Read more at https://cushings.invisionzone.com/topic/57575-development-of-human-pituitary-neuroendocrine-tumor-organoids-to-facilitate-effective-targeted-treatments-of-cushing%E2%80%99s-disease/

I have often said, I wish I had cancer instead.  Most people would not understand this sentiment, why in the world would you wish for such a horrible disease?...

Read more at https://cushieblogger.com/2019/04/04/from-a-past-blogging-challenge-cushings-awareness-challenge-danielle-day-4/

Cushing’s syndrome due to ectopic adrenocorticotropic hormone (ACTH) secretion (EAS) by a pheochromocytoma is a challenging condition. 

Read more at https://cushings.invisionzone.com/topic/57606-catastrophic-acth-secreting-pheochromocytoma/

The Cushing’s syndrome, a disease caused by the excessive production of cortisol by the pituitary gland due to a benign tumor of the gland, has seen a breakthrough in its treatment. Thanks to a new drug called osilodrostat, approved in 2020 by the Food and Drug Administration and subsequently by Aifa in Italy, patients unfit for surgery can benefit from a treatment that offers the same effects as a scalpel. Furthermore, this drug reduced symptoms in 80% of cases.

Read more at https://cushings.invisionzone.com/topic/57612-cushing%E2%80%99s-syndrome-a-new-drug-allows-you-to-avoid-surgery/

Cushing’s disease is a progressive pituitary disorder in which there is an excess of cortisol in the body. While the disease can be treated surgically, this option is not possible for all patients. This is one of the approved medications that assist in controlling cortisol levels in people with Cushing’s disease.

Isturisa was approved in 2020 to treat adults with Cushing’s disease for whom pituitary surgery is ineffective or not an option.

Read more at https://cushings.invisionzone.com/topic/56571-meds-isturisa/

Ectopic pituitary adenoma (EPA) is a pituitary adenoma unrelated to the intrasellar component and is an extremely rare disease.

Read more at https://cushings.invisionzone.com/topic/57535-ectopic-adrenocorticotropic-hormone-secreting-pituitary-adenoma-in-the-clivus-region-a-case-report/

The most common cause of Cushing syndrome (CS) is exposure to exogenous glucocorticoids. There is an increasing incidence of adulterated over-the-counter (OTC) supplements containing steroids.

Read more at https://cushings.invisionzone.com/topic/57624-exogenous-cushing-syndrome-and-hip-fracture-due-to-over-the-counter-supplement-artri-king/

Myth: “Cushing’s is RARE”, “No one has Cushing’s!”, “It is literally impossible for you to have Cushing’s Disease!”

Read more at https://cushieblogger.com/2021/04/04/cushings-myths-and-facts-cushings-is-rare-no-one-has-cushings-3/

TSH stands for “thyroid stimulating hormone” and the test measures how much of this hormone is in your blood. TSH is produced by the pituitary gland in your brain. This gland tells your thyroid to make and release the thyroid hormones into your blood.

Read more at https://cushings.invisionzone.com/topic/56343-basics-testing-what-is-a-tsh-test/

Patients with neuroendocrine tumors before ectopic Cushing syndrome development were more likely metastatic and had worse survival

Read more at https://cushings.invisionzone.com/topic/56894-management-of-adrenocorticotropic-hormone-secreting-neuroendocrine-tumors-and-the-role-of-bilateral-adrenalectomy-in-ectopic-cushing-syndrome/

The higher IGF-1 index was independently associated with lower prevalence of low bone mass in young CD patients, and IGF-1 might play an important role in the pathogenesis of CD-caused low bone mass.

Read more at https://cushings.invisionzone.com/topic/57619-association-of-igf-1-level-with-low-bone-mass-in-young-patients-with-cushing%E2%80%99s-disease/

Ectopic Cushing’s syndrome due to metastatic neuroendocrine small-cell carcinoma is a rare condition with a poor prognosis. The options for treatment are few and not necessarily curative. There needs to be increased awareness of this serious and rare complication. Managing the condition can be a challenge and requires a multidisciplinary team approach to improve outcomes.

Read more at https://cushings.invisionzone.com/topic/57577-recurrent-neuroendocrine-tumor-of-the-cervix-presenting-with-ectopic-cushing%E2%80%99s-syndrome/

The founder of Adrenal Alternatives Foundation has suffered a severe adrenal crisis yesterday morning. She is alive but fighting for her life.
We are unsure of the status of the Foundation at this time.

This is the unfortunate reality of this disease, not even the strongest ones are exempt from the toll it takes. Keep fighting, adrenal warriors.

Read more at https://cushings.invisionzone.com/topic/57593-please-pray-for-the-founder-of-the-adrenal-alternatives-foundation/

Osilodrostat provided long-term control of cortisol secretion that was associated with sustained improvements in clinical signs and physical manifestations of hypercortisolism. Osilodrostat is an effective long-term treatment for patients with Cushing’s disease.

Read more at https://cushings.invisionzone.com/topic/57632-long-term-efficacy-and-safety-of-osilodrostat-in-patients-with-cushing%E2%80%99s-disease/

This extended evaluation (EE) of the SONICS study assessed effects of levoketoconazole for an additional 6 months following open-label, 6-month maintenance treatment in endogenous Cushing’s syndrome.

Read more at https://cushings.invisionzone.com/topic/57576-levoketoconazole-treatment-in-endogenous-cushing%E2%80%99s-syndrome/

More from Facebook, 2022 - Janice said 'I’m so happy that you documented your life. And am grateful you gave up so Much of your life to raise awareness for our disease....If it weren’t for the support that you have provided all of us over the years life would be so Much more difficult. Thanks for everything you’ve done and continue to do'

Marie said 'Congrats
 to you on this special anniversary! I feel so honored and blessed to have met you on a few occasions and most grateful for your visit at NIH while I was there for 3 weeks. Thank you so much for your kindness and support! They meant alot to me!'

Judy said 'Thank you, thank you, thank you....'

Aemi said 'Amazing. Thank you for sharing your story and for continuing to educate doctors on Cushings!'

From https://cushingsbios.com/2021/11/03/maryo-34th-pituitary-surgery-anniversary/

Social media dominates most people's lives these days. You see what everyone you know is up to, but the problem is, most people only post about the highlights of their lives.

You don't get to see the low points, the every day struggles. You don't see what keeps them up at night with worry...

Read more at https://cushieblogger.com/2019/04/05/from-a-past-blogging-challenge-cushings-awareness-challenge-danielle-day-5/

A 35-year-old woman is seen in the outpatient clinic for evaluation of an incidental pituitary macroadenoma. Her medical history is significant for hypertension, diabetes, hyperlipidemia, polycystic ovary syndrome, and obesity. She initially presented to the emergency department (ED) a week ago after an episode of right visual field changes that she described as waviness in her right eye and right hemibody sensory changes without motor deficits. While in the ED, she underwent a full workup for possible stroke, which was negative. Magnetic resonance imaging (MRI) of her brain without contrast revealed a 12-mm pituitary lesion; a repeat MRI with contrast was then ordered (Figure). No serum hormonal panel was available for review from ED records. 

Read more at https://cushings.invisionzone.com/topic/56643-workup-for-incidental-pituitary-adenoma/

Interview with Alicia, a Cushing’s Message Board member who is still testing. Alicia writes “Around the end of my Junior year, probably one of the worst things that could have happened during my 8 years of illness happened, I had severe psychiatric symptoms at school, including psychosis, and was put on a “students in crisis” plan and sent home for a little while. Being diagnosed as a “psych patient” would delay my diagnosis for years, most doctors just considered me “crazy.”

Read more at https://cushieblogger.com/2019/04/05/archived-interview-with-alicia-a-patient-who-is-still-testing/

The most common cause of Cushing syndrome (CS) is exposure to exogenous glucocorticoids. There is an increasing incidence of adulterated over-the-counter (OTC) supplements containing steroids.

Read more at https://cushings.invisionzone.com/topic/57624-exogenous-cushing-syndrome-and-hip-fracture-due-to-over-the-counter-supplement-artri-king/

Patients with neuroendocrine tumors before ectopic Cushing syndrome development were more likely metastatic and had worse survival

Read more at https://cushings.invisionzone.com/topic/56894-management-of-adrenocorticotropic-hormone-secreting-neuroendocrine-tumors-and-the-role-of-bilateral-adrenalectomy-in-ectopic-cushing-syndrome/

The higher IGF-1 index was independently associated with lower prevalence of low bone mass in young CD patients, and IGF-1 might play an important role in the pathogenesis of CD-caused low bone mass.

Read more at https://cushings.invisionzone.com/topic/57619-association-of-igf-1-level-with-low-bone-mass-in-young-patients-with-cushing%E2%80%99s-disease/

Ectopic Cushing’s syndrome due to metastatic neuroendocrine small-cell carcinoma is a rare condition with a poor prognosis. The options for treatment are few and not necessarily curative. There needs to be increased awareness of this serious and rare complication. Managing the condition can be a challenge and requires a multidisciplinary team approach to improve outcomes.

Read more at https://cushings.invisionzone.com/topic/57577-recurrent-neuroendocrine-tumor-of-the-cervix-presenting-with-ectopic-cushing%E2%80%99s-syndrome/

After your physicians have determined that it is reasonably safe to discharge you from the hospital following transsphenoidal pituitary surgery there are a number of important situations that may arise. Most people feel well after discharge. However, you should be aware of these possible problems, just in case. The following general guidelines are provided to promote your health and safety.

Headache, facial, and sinus pain are not uncommon following pituitary surgery. As you may have noted, the pain and discomfort typically improve on a daily basis following surgery. If you should experience a worsening of your pain or discomfort, please contact your neurosurgeon immediately.

Read more at http://www.cushings-info.com/index.php?title=Pituitary_Post-Op

Despite improved outcomes in recent years, increased mortality from CS persists. The causes of death highlight the need to prevent and manage co-morbidities in addition to treating hypercortisolism.

Read more at https://cushings.invisionzone.com/topic/56897-the-effect-of-endogenous-cushings-syndrome-on-all-cause-and-cause-specific-mortality/

Sharmyn McGraw knows as much about pituitary disease as some doctors. She learned about it after struggling for years with a medical mystery that began in 1993.

First, she began to feel anxious. Then, she began to gain weight, and she developed a rash. Much of her hair fell out. Her eyes began to yellow and her face puffed up.

Read more at https://cushings.invisionzone.com/topic/56898-tracking-a-mystery-disease-to-the-pituitary-gland-sharmyn-mcgraw/

The most common cause of Cushing syndrome (CS) is exposure to exogenous glucocorticoids. There is an increasing incidence of adulterated over-the-counter (OTC) supplements containing steroids.

Read more at https://cushings.invisionzone.com/topic/57624-exogenous-cushing-syndrome-and-hip-fracture-due-to-over-the-counter-supplement-artri-king/

Patients with neuroendocrine tumors before ectopic Cushing syndrome development were more likely metastatic and had worse survival

Read more at https://cushings.invisionzone.com/topic/56894-management-of-adrenocorticotropic-hormone-secreting-neuroendocrine-tumors-and-the-role-of-bilateral-adrenalectomy-in-ectopic-cushing-syndrome/

The higher IGF-1 index was independently associated with lower prevalence of low bone mass in young CD patients, and IGF-1 might play an important role in the pathogenesis of CD-caused low bone mass.

Read more at https://cushings.invisionzone.com/topic/57619-association-of-igf-1-level-with-low-bone-mass-in-young-patients-with-cushing%E2%80%99s-disease/

Ectopic Cushing’s syndrome due to metastatic neuroendocrine small-cell carcinoma is a rare condition with a poor prognosis. The options for treatment are few and not necessarily curative. There needs to be increased awareness of this serious and rare complication. Managing the condition can be a challenge and requires a multidisciplinary team approach to improve outcomes.

Read more at https://cushings.invisionzone.com/topic/57577-recurrent-neuroendocrine-tumor-of-the-cervix-presenting-with-ectopic-cushing%E2%80%99s-syndrome/

Cortisol is a hormone which produced by the adrenal gland (cortex) to control blood sugar. The production of cortisol is triggered by the pituitary hormone ACTH. Cortisol is a glucocorticoid which stimulates an increase in blood glucose. Cortisol will also stimulate the release of amino acids from muscle tissue and fatty acids from adipose tissue. The amino acids are then converted in the liver to glucose (for use by the brain). The fatty acids can be used by skeletal muscles for energy (rather than glucose) thereby freeing up glucose for selective utilization by the brain. Cortisol levels are often measured to evaluate the function of the pituitary or adrenal glands. Some of the cortisol is metabolized by the liver to produce 17 hydroxycorticosteroids, which is then excreted in the urine.

Read more at https://cushings.invisionzone.com/topic/56255-what-is-cortisol/

We describe the first report of recurrent Cushing's Disease that was quiescent during pregnancy and diagnosed in the immediate postpartum period. Understanding the risk and mechanisms of CD recurrence in pregnancy allows us to counsel these otherwise healthy, reproductive-age women in the context of additional family planning.

Read more at https://cushings.invisionzone.com/topic/57548-persistent-vs-recurrent-cushing%E2%80%99s-disease-diagnosed-four-weeks-postpartum/

Ectopic ACTH-producing pituitary adenoma (EAPA) of the clivus region is extraordinarily infrequent condition and merely a few reports have been reported to date.

The patient was a 53-year-old woman who presented with Cushing-like appearances and a soft tissue mass in the clivus region.

Read more at https://cushings.invisionzone.com/topic/57614-cushing%C2%A0syndrome-caused-by-an%C2%A0ectopic-acth-producing-pituitary-adenoma%C2%A0of-the%C2%A0clivus-region/

Bilateral adrenalectomy (BA) still plays an important role in the management of Cushing's disease (CD). Nelson’s syndrome (NS) is a severe complication of BA, but conflicting data on its prevalence and predicting factors have been reported. The aim of this study was to determine the prevalence of NS, and identify factors associated with its development.

Read more at https://cushings.invisionzone.com/topic/55708-prevalence-of-nelson%E2%80%99s-syndrome-after-bilateral-adrenalectomy-in-patients-with-cushing%E2%80%99s-disease/

Acute adrenal crisis is a life-threatening state caused by insufficient levels of cortisol, which is a hormone produced and released by the adrenal gland.

Read more at https://cushings.invisionzone.com/topic/56238-call-911-adrenal-crisis-addisonsadrenal-insufficiency/

The pituitary gland produces hormones. A tumor in this gland can cause it to produce too much of the hormone cortisol. Too much cortisol in the body causes Cushing disease. This disease causes many problems. Some of these problems might persist after the disease is cured.

Read more at https://cushings.invisionzone.com/topic/56742-long-term-follow-up-of-survivors-of-pediatric-cushing-disease/

Please consider joining us for #Pituitary Tumor Support Group on Saturday October 7th, 2023 at 9am to discuss Current and Emerging Medical Therapies in Pituitary Tumor Treatment by Dr. Mahalakshi Honasage, #Endocrinologist, and Dr. Jack Rock, #Neurosurgery.

More information at https://cushings.invisionzone.com/topic/57635-pituitary%C2%A0tumor-support-group/#comment-478468

October 7 @ 9:00 am – 1:00 pm

The annual Pituitary Patient Education Day is a free event that features presentations from Johns Hopkins pituitary experts.

To RSVP, please email pituitaryday@jhmi.edu. Space is limited. One member per family is encouraged to attend.

Read more at https://cushings.invisionzone.com/topic/57631-johns-hopkins-pituitary-patient-education-day/