Cushing’s disease (CD) is an extremely rare diagnosis in children. In this report, we present the case of an almost 16-year-old, short and thin boy with CD, the first symptoms of which were spinal pain and vertebral fractures as a result of osteoporosis. In light of his growth retardation and short stature, the boy underwent diagnostics, which excluded growth hormone (GH) deficiency, hypothyroidism and celiac disease. Finally, based on cortisol profile results, dexamethasone suppression tests and bilateral sampling during catheterization of the inferior petrosal sinuses, CD was diagnosed.

Read more at https://cushings.invisionzone.com/topic/57647-osteoporosis-as-the-first-sign-of-cushing%E2%80%99s-disease-in-a-thin-16-year-old-boy/

We present a 9-year-old boy who presented at age 4 with cyclical Cushing syndrome and was eventually diagnosed with a novel, previously unreported, unpublished variant in PRKAR1A associated with Carney complex. He was treated with unilateral left adrenalectomy. At 1-year follow-up, he continues to be in remission of his symptoms of Cushing syndrome.

https://cushings.invisionzone.com/topic/57870-unilateral-adrenalectomy-for-pediatric-cyclical-cushing-syndrome-with-novel-prkar1a-variant-associated-carney-complex/

Dr. Friedman will be joined by Brittany Henderson, MD, ECNU for an exciting GoodHormoneHeath Webinar on Dueling Academic-Based Endocrinologists discussing state-of-the-art hypothyroidism diagnosis and treatment: Commonalities and Differences

https://cushings.invisionzone.com/topic/57875-save-the-date-dueling-endocrinologists-discussing-hypothyroidism-diagnosis-and-treatment-commonalities-and-differences/

Cushing’s syndrome with concurrent primary aldosteronism (PA) is a rare presentation, and establishing an early diagnosis is imperative to preventing morbidity and long-term sequelae. The diagnosis is established by sequential lab work, showing an elevated cortisol and aldosterone level.

Read more at https://cushings.invisionzone.com/topic/57634-rare-challenges-in-diagnosing-cushing%E2%80%99s-syndrome-and-primary-aldosteronism-a-case-report-of-a-female-with-a-negative-workup/

Bone material properties remain altered in patients with endogenous CS, even after long-term remission. These abnormalities, known to be associated with fractures in other populations, may play a role in the persistent bone fragility of steroid excess.

https://cushings.invisionzone.com/topic/57772-bone-material-strength-index-is-low-in-patients-with-cushings-syndrome-even-after-long-term-remission/

The most common cause of Cushing syndrome (CS) is exposure to exogenous glucocorticoids. There is an increasing incidence of adulterated over-the-counter (OTC) supplements containing steroids.

Read more at https://cushings.invisionzone.com/topic/57624-exogenous-cushing-syndrome-and-hip-fracture-due-to-over-the-counter-supplement-artri-king/

The higher IGF-1 index was independently associated with lower prevalence of low bone mass in young CD patients, and IGF-1 might play an important role in the pathogenesis of CD-caused low bone mass.

Read more at https://cushings.invisionzone.com/topic/57619-association-of-igf-1-level-with-low-bone-mass-in-young-patients-with-cushing%E2%80%99s-disease/

Ectopic Cushing’s syndrome due to metastatic neuroendocrine small-cell carcinoma is a rare condition with a poor prognosis. The options for treatment are few and not necessarily curative. There needs to be increased awareness of this serious and rare complication. Managing the condition can be a challenge and requires a multidisciplinary team approach to improve outcomes.

Read more at https://cushings.invisionzone.com/topic/57577-recurrent-neuroendocrine-tumor-of-the-cervix-presenting-with-ectopic-cushing%E2%80%99s-syndrome/

Cushing's syndrome (CS) is a rare disease with multiple somatic signs and a high prevalence of co-occurring depression. However, the characteristics of depression secondary to CS and the differences from major depression have not been described in detail. In this case, we report a 17-year-old girl with treatment-resistant depression with a series of atypical features and acute psychotic episodes, which is a rare condition secondary to CS.

Read more at https://cushings.invisionzone.com/topic/57625-treatment-resistant-depression-with-acute-psychosis-in-an-adolescent-girl-with-cushings-syndrome/

Cushing’s disease may sometimes make you feel that your life is out of your control. But there are some general things you can do to help take back control.

https://cushings-help.com/2024/11/05/tips-for-living-with-cushings/

Join NADF for the first annual virtual conference for patients and caregivers, 'Navigating Adrenal Health'. With talks on topics ranging from research updates to accessing patient resources to EMS standards and expectations, participants can prepare for a wealth of information for patients, caregivers, and clinicians alike.

https://cushings.invisionzone.com/topic/57871-webinar-navigating-adrenal-health/

Graphic Era Hospital has achieved a remarkable mileston by successfully treating two complex cases of the rare hormonal disorder Cushing’s Disease in Dehradun. The hospital’s experts used advanced technology and surgical skills to give the patients a new lease on life, marking this significant achievement.

https://cushings.invisionzone.com/topic/57868-graphic-era-hospital%E2%80%99s-milestone-treatment-of-two-complex-cases/

Posterior pituitary tumors (PPTs) are extremely rare, with fewer than 400 cases reported to date. In 2022, the WHO classified four types of tumors originating from the posterior pituitary

Read more at https://cushings.invisionzone.com/topic/57780-oncocytic-pituicytoma-in-a-patient-with-cushings-disease/

Anita is from Rye, Colorado

She was diagnosed with Cushing's in the summer of 2020 and now has an adrenal adenoma on heright.

Read more at https://cushingsbios.com/2022/10/15/anita-s-adrenal-bio/

We report the case of a 53-year-old female patient who presented with severe Cushing’s syndrome and was diagnosed with ectopic ACTH syndrome. Despite initial indications pointing towards pituitary-dependent hypercortisolism, further investigations revealed the presence of a highly differentiated atypically located tumor in the upper lobe of the left lung, adjacent to the mediastinum. Immunohistochemistry of the tumor tissue demonstrated not only ACTH but also CRH and CRH-R1 expression.

https://cushings.invisionzone.com/topic/57795-ectopic-crhacth-co-secreting-neuroendocrine-tumors-leading-to-cushings-disease/

The annual Pituitary Patient Education Day is a free event that features presentations from Johns Hopkins pituitary experts.

https://cushings.invisionzone.com/topic/57826-johns-hopkins-pituitary-patient-education-day/

We present a 9-year-old boy who presented at age 4 with cyclical Cushing syndrome and was eventually diagnosed with a novel, previously unreported, unpublished variant in PRKAR1A associated with Carney complex. He was treated with unilateral left adrenalectomy. At 1-year follow-up, he continues to be in remission of his symptoms of Cushing syndrome.

https://cushings.invisionzone.com/topic/57870-unilateral-adrenalectomy-for-pediatric-cyclical-cushing-syndrome-with-novel-prkar1a-variant-associated-carney-complex/

Pasireotide is the first pituitary-directed approved therapy for Cushing’s disease (CD), effective in reducing 24 h urine free cortisol (UFC) > 50% in more than half of patients, with beneficial effects and with a relatively high incidence of hyperglycemia. The aim of this study was to evaluate efficacy and safety of long-term treatment with pasireotide (PAS) in CD patients, also according to gender.

https://cushings.invisionzone.com/topic/57812-efficacy-and-safety-of-pasireotide-in-patients-with-cushing%E2%80%99s-disease/

Cushing's awareness discussions come out in the oddest ways.

Last night, we were out at a Lebanese restaurant couple with a young couple from India and were talking about foods we liked.  I said that I liked spicy foods in general.

That led to the fact that I haven't had a good sense of smell since my transsphenoidal surgery and that things taste better when I can smell them.  That got us around to why I'd had the surgery and what the symptoms of Cushing's are....

Read more at https://cushings.invisionzone.com/topic/56835-day-15-cushing%E2%80%99s-awareness-challenge-2022/?do=findComment&comment=478739

The most common cause of Cushing syndrome (CS) is exposure to exogenous glucocorticoids. There is an increasing incidence of adulterated over-the-counter (OTC) supplements containing steroids.

Read more at https://cushings.invisionzone.com/topic/57624-exogenous-cushing-syndrome-and-hip-fracture-due-to-over-the-counter-supplement-artri-king/

The higher IGF-1 index was independently associated with lower prevalence of low bone mass in young CD patients, and IGF-1 might play an important role in the pathogenesis of CD-caused low bone mass.

Read more at https://cushings.invisionzone.com/topic/57619-association-of-igf-1-level-with-low-bone-mass-in-young-patients-with-cushing%E2%80%99s-disease/

Cushing’s disease is a progressive pituitary disorder in which there is an excess of cortisol in the body. While the disease can be treated surgically, this option is not possible for all patients. This is one of the approved medications that assist in controlling cortisol levels in people with Cushing’s disease.

Korlym (mifepristone), developed and marketed by Corcept Therapeutics, is an FDA-approved treatment for high blood sugar (hyperglycemia) in adults with Cushing’s syndrome who have type 2 diabetes or glucose intolerance, and for whom surgery is not an option, or failed to control their symptoms.

Read more at https://cushings.invisionzone.com/topic/56598-basics-meds-korlym/

Ectopic Cushing’s syndrome due to metastatic neuroendocrine small-cell carcinoma is a rare condition with a poor prognosis. The options for treatment are few and not necessarily curative. There needs to be increased awareness of this serious and rare complication. Managing the condition can be a challenge and requires a multidisciplinary team approach to improve outcomes.

Read more at https://cushings.invisionzone.com/topic/57577-recurrent-neuroendocrine-tumor-of-the-cervix-presenting-with-ectopic-cushing%E2%80%99s-syndrome/

Cushing syndrome characteristically presents with skin changes such as facial plethora, easy bruising, and purple striae and with metabolic manifestations such as hyperglycemia, hypertension, and excess fat deposition in the face, back of the neck, and visceral organs. 

Read more at https://cushings.invisionzone.com/topic/57616-basics-cushing-syndrome-a-review/

Like most everything else in my life, having had Cushing's (pituitary) made this surgery more difficult.  My surgeon had to plan with my endocrinologist how much cortisol I'd need during the operation, then I had to stay overnight to get me successfully weaned off the cortisone again.

Read more at https://cushings.invisionzone.com/topic/57682-what-was-the-most-memorable-thing-that-happened-to-you-last-year/

The purpose was to assess coronary inflammation by measuring the volume and density of the epicardial adipose tissue (EAT), perivascular fat attenuation index (FAI) and coronary plaque burden in patients with Cushing’s syndrome (CS) based on coronary computed tomography angiography (CCTA).

Read more at https://cushings.invisionzone.com/topic/57700-epicardial-and-pericoronary-adipose-tissue-and-coronary-plaque-burden-in-patients-with-cushing%E2%80%99s-syndrome/

Cushing’s disease may sometimes make you feel that your life is out of your control. But there are some general things you can do to help take back control.

https://cushings-help.com/2024/11/05/tips-for-living-with-cushings/

Join NADF for the first annual virtual conference for patients and caregivers, 'Navigating Adrenal Health'. With talks on topics ranging from research updates to accessing patient resources to EMS standards and expectations, participants can prepare for a wealth of information for patients, caregivers, and clinicians alike.

https://cushings.invisionzone.com/topic/57871-webinar-navigating-adrenal-health/

Primary pigmented nodular adrenocortical disease (PPNAD) is a rare but important cause of adrenocorticotropic hormone (ACTH)-independent Cushing syndrome (CS). It usually presents as cyclical CS in young adults. Childhood onset of PPNAD is exceedingly rare. About 90% of cases of PPNAD are associated with Carney complex (CNC).

https://cushings.invisionzone.com/topic/57796-a-rare-case-of-prkaca-duplication%E2%80%93associated-childhood-onset-primary-pigmented-nodular-adrenocortical-disease/

Graphic Era Hospital has achieved a remarkable mileston by successfully treating two complex cases of the rare hormonal disorder Cushing’s Disease in Dehradun. The hospital’s experts used advanced technology and surgical skills to give the patients a new lease on life, marking this significant achievement.

https://cushings.invisionzone.com/topic/57868-graphic-era-hospital%E2%80%99s-milestone-treatment-of-two-complex-cases/

Posterior pituitary tumors (PPTs) are extremely rare, with fewer than 400 cases reported to date. In 2022, the WHO classified four types of tumors originating from the posterior pituitary

Read more at https://cushings.invisionzone.com/topic/57780-oncocytic-pituicytoma-in-a-patient-with-cushings-disease/

Jenn (StaceyJenn) was diagnosed with adrenal insufficiency, hypothyroidism, and a host of other ailments in 2001 (candidiasis, intestinal permeability, 22 latent food allergies). Once diagnosed, she was on specially formulated hydrocortisone for 7 years as she was allergic to the fillers in the meds...

Listen at https://cushieblogger.com/2019/04/15/archived-interview-jenn-steroid-induced-iatrogenic-cushings-patient/

This study suggests that BIPSS may be a reliable and low-complication technique in evaluating patients with ACTH-dependent CS who had inconclusive imaging and biochemical test results. The diagnostic accuracy is improved by DDAVP stimulation. Pituitary adenoma lateralization can be predicted with the aid of BIPSS.

Read more at https://cushings.invisionzone.com/topic/57666-bilateral-inferior-petrosal-sinus-sampling-validity-diagnostic-accuracy-in-lateralization-of-pituitary-microadenoma-and-treatment-in-eleven-patients-with-cushing%E2%80%99s-syndrome-%E2%80%93-a-single-center-retrospective-cohort-study/

The Add Your Bio form has been updated so that it no longer requires Flash. Your information will help others.

I would like to add that if anyone would like to do something for the Cushing's Awareness Challenge but you don't have (or want to have) a blog, why not consider adding your bio to the website this month?

More info at https://cushingsbios.com/2018/08/28/we-have-a-new-bio-form/

The tumour affected teenager Niall’s pituitary gland, resulting in a condition known as hypopituitarism.

Read more at https://cushingsbios.com/2023/10/16/teenager-overcomes-brain-tumour-and-shares-his-experience-hypopituitarism/

In Cushing syndrome (CS), prolonged exposure to high cortisol levels results in a wide range of devastating effects causing multisystem morbidity. 

Read more at https://cushings.invisionzone.com/topic/57717-epigenetic-mechanisms-modulated-by-glucocorticoids-with-a-focus-on-cushing-syndrome/

We present a 9-year-old boy who presented at age 4 with cyclical Cushing syndrome and was eventually diagnosed with a novel, previously unreported, unpublished variant in PRKAR1A associated with Carney complex. He was treated with unilateral left adrenalectomy. At 1-year follow-up, he continues to be in remission of his symptoms of Cushing syndrome.

https://cushings.invisionzone.com/topic/57870-unilateral-adrenalectomy-for-pediatric-cyclical-cushing-syndrome-with-novel-prkar1a-variant-associated-carney-complex/

Boy, I really needed to reread this again today.

Many thanks again...to me!...for sharing.

Except for my new 'hobby' of learning the balalaika, everything is seeming painful, blah, boring and, at times, plain annoying.

Read more at https://cushings.invisionzone.com/topic/56844-day-16-cushing%E2%80%99s-awareness-challenge-2022/?do=findComment&comment=478742

The FDA has expanded the approval of belzutifanopens in a new tab or window (Welireg) to include certain types of pheochromocytoma or paraganglioma (PPGL) in adults and children.

The action establishes belzutifan as the only approved oral therapy for PPGL. The approval stipulates use in adults and children 12 years or older with locally advanced, unresectable, or metastatic PPGL.

https://cushings.invisionzone.com/topic/57827-first-oral-therapy-for-rare-adrenal-gland-tumors-gets-green-light-from-fda/

Video, personal stories and 'official information'. 

The MRI still showed nothing, so they did a Petrosal Sinus Sampling Test. That scared me more than the prospect of surgery. (This test carries the risk of stroke and uncontrollable bleeding from the incision points.)

Catheters were fed from my groin area to my pituitary gland and dye was injected. I could watch the whole procedure on monitors. I could not move during this test or for several hours afterwards to prevent uncontrollable bleeding from a major artery.

The test did show where the tumor probably was located...

Read more at https://cushings.invisionzone.com/topic/56225-testing-inferior-petrosal-sinus-sampling/

The goal is to leave some normal adrenal tissue so that the patient can avoid adrenal insufficiency which requires a daily dose of several adrenal hormones and steroids. Partial adrenal surgery is especially beneficial for patients with pheochromocytoma, as well as Conn's and Cushing's syndrome. Avoiding daily steroids is life-changing for these patients so this is a major breakthrough.'

Read more at https://cushings.invisionzone.com/topic/56841-novel-application-of-amniotic-membrane-saves-adrenal-tissue-in-patients-undergoing-adrenal-surgery/

The most common cause of Cushing syndrome (CS) is exposure to exogenous glucocorticoids. There is an increasing incidence of adulterated over-the-counter (OTC) supplements containing steroids.

Read more at https://cushings.invisionzone.com/topic/57624-exogenous-cushing-syndrome-and-hip-fracture-due-to-over-the-counter-supplement-artri-king/

I have a tumour on my right adrenal gland and diagnosed with Cushings 3 years ago . Covid got in the way of surgery initially so now I wait and I wait. I try to keep going but I really just want to stay in bed as I’ve little energy, poor concentration and less interest…

Read more at https://cushingsbios.com/2016/08/23/niamh-niamhiblog-adrenal-bio/

The higher IGF-1 index was independently associated with lower prevalence of low bone mass in young CD patients, and IGF-1 might play an important role in the pathogenesis of CD-caused low bone mass.

Read more at https://cushings.invisionzone.com/topic/57619-association-of-igf-1-level-with-low-bone-mass-in-young-patients-with-cushing%E2%80%99s-disease/

Ectopic Cushing’s syndrome due to metastatic neuroendocrine small-cell carcinoma is a rare condition with a poor prognosis. The options for treatment are few and not necessarily curative. There needs to be increased awareness of this serious and rare complication. Managing the condition can be a challenge and requires a multidisciplinary team approach to improve outcomes.

Read more at https://cushings.invisionzone.com/topic/57577-recurrent-neuroendocrine-tumor-of-the-cervix-presenting-with-ectopic-cushing%E2%80%99s-syndrome/

Pheochromocytoma and Cushing's syndrome are rare endocrine conditions caused by tumors in the adrenal gland. These conditions are classified under Multiple Endocrine Neoplasia (MEN) syndrome...

Read more at https://cushings.invisionzone.com/topic/57627-asymptomatic-pheochromocytoma-associated-with-men-syndrome-and-subclinical-cushings-syndrome/

Doctors delayed the surgery until he got a CT scan, which did not confirm a lung nodule but did find one on an adrenal gland. Again, doctors postponed surgery to allow for further work-up of the adrenal nodule, which was ultimately found to be benign. The man finally had his hernia repaired after six additional months of debilitating pain and repeated anxiety over incidental test findings suggesting he could have cancer.

From https://www.nytimes.com/2021/11/15/well/live/surgery-medical-tests.html

Pseudo-Cushing’s syndrome is when symptoms are similar to those of Cushing’s syndrome, but further tests show that the syndrome is not present.

Read more at https://cushings.invisionzone.com/topic/57556-basics-pseudo-cushing%E2%80%99s-syndrome/

Cushing’s syndrome is associated with early medical- and surgical-related complications following total joint arthroplasty and a reduced incidence of manipulation under anesthesia following total knee arthroplasty.

Read more at https://cushings.invisionzone.com/topic/57607-cushing%E2%80%99s-syndrome-is-associated-with-early-medical-and-surgical-related-complications-following-total-joint-arthroplasty/

Cushing’s disease may sometimes make you feel that your life is out of your control. But there are some general things you can do to help take back control.

https://cushings-help.com/2024/11/05/tips-for-living-with-cushings/

Join NADF for the first annual virtual conference for patients and caregivers, 'Navigating Adrenal Health'. With talks on topics ranging from research updates to accessing patient resources to EMS standards and expectations, participants can prepare for a wealth of information for patients, caregivers, and clinicians alike.

https://cushings.invisionzone.com/topic/57871-webinar-navigating-adrenal-health/

Doctors should suspect Cushing’s syndrome when they see patients with purple stretch marks and metabolic conditions such as diabetes, even if those symptoms aren’t the reasons for a medical visit, physicians in Japan wrote in a case study describing how they reached that diagnosis for a woman in her early 30s.

Read more at https://cushings.invisionzone.com/topic/57701-violaceous-abdominal-striae-noted-on-physical-examination-a-clue-to-the-diagnosis-of-cushing%E2%80%99s-syndrome/

A lot of Cushing’s patients are getting diagnosed and treated in primary care, which is completely appropriate. But I’ve also met endocrinologists who are uncomfortable diagnosing and managing Cushing’s because it is so rare,” she said.

Read more at https://cushings.invisionzone.com/topic/57755-insights-on-diagnosing-and-managing-cushing%E2%80%99s-syndrome/

Patients with endogenous Cushing’s syndrome (CS) have elevated mortality, particularly during active disease. A recent meta-analysis reported reduced mortality rates after 2000 in adrenal CS and Cushing disease (CD), though many studies lacked population-matched controls.

https://cushings.invisionzone.com/topic/57813-mortality-in-cushing%E2%80%99s-syndrome-declining-over-two-decades-but-remaining-higher-than-the-general-population/

Relacorilant works differently than other agents indicated for endogenous hypercortisolism (also known as Cushing's syndrome) like the nonselective glucocorticoid receptor antagonist mifepristone (Korlym), which can be difficult to use given its drug-drug interactions and side effects like endometrial hypertrophy and vaginal bleeding.

https://cushings.invisionzone.com/topic/57853-novel-cushings-syndrome-drug-improves-hypertension-hyperglycemia/

Graphic Era Hospital has achieved a remarkable mileston by successfully treating two complex cases of the rare hormonal disorder Cushing’s Disease in Dehradun. The hospital’s experts used advanced technology and surgical skills to give the patients a new lease on life, marking this significant achievement.

https://cushings.invisionzone.com/topic/57868-graphic-era-hospital%E2%80%99s-milestone-treatment-of-two-complex-cases/

Posterior pituitary tumors (PPTs) are extremely rare, with fewer than 400 cases reported to date. In 2022, the WHO classified four types of tumors originating from the posterior pituitary

Read more at https://cushings.invisionzone.com/topic/57780-oncocytic-pituicytoma-in-a-patient-with-cushings-disease/

Terry (Terry) is a long time pituitary Cushing’s survivor. Terry had a pituitary surgery (in LA) in October of 2003 which did not cure her Cushing’s Disease. Then, Dec 13th, 2003 she had her BLA in a Wisconsin hospital. She also had an infection in her sphenoid sinus. It originated at the site of her pituitary surgery from October 2003. She had to be on a lot of antibiotics and narcotic pain relievers. In Sept 2005 the surgeon remove the infection from one area, making another area clear…..

Listen at  https://cushieblogger.com/2019/04/16/archived-interview-terry-g-pituitary-patient/

Cortical tumors are particularly rare among children with AIs and are sometimes not clearly distinguishable from neurogenic tumors on preoperative imaging; in such patients, the presence of subclinical Cushing’s syndrome needs to be carefully evaluated preoperatively; otherwise, a perioperative adrenal crisis may occur [21]. In patients in whom the possibility of an adrenocortical tumor was considered preoperatively, the assessment for subclinical Cushing’s syndrome mainly involved assessing the serum dehydroepiandrosterone sulfate level and performing an overnight dexamethasone suppression test.

Read more at https://cushings.invisionzone.com/topic/57702-clinical-features-and-treatment-options-for-pediatric-adrenal-incidentalomas/

We present a 9-year-old boy who presented at age 4 with cyclical Cushing syndrome and was eventually diagnosed with a novel, previously unreported, unpublished variant in PRKAR1A associated with Carney complex. He was treated with unilateral left adrenalectomy. At 1-year follow-up, he continues to be in remission of his symptoms of Cushing syndrome.

https://cushings.invisionzone.com/topic/57870-unilateral-adrenalectomy-for-pediatric-cyclical-cushing-syndrome-with-novel-prkar1a-variant-associated-carney-complex/

The most common cause of Cushing syndrome (CS) is exposure to exogenous glucocorticoids. There is an increasing incidence of adulterated over-the-counter (OTC) supplements containing steroids.

Read more at https://cushings.invisionzone.com/topic/57624-exogenous-cushing-syndrome-and-hip-fracture-due-to-over-the-counter-supplement-artri-king/

CS is treated through surgical procedures based on the detected lesions. Patients with severe CS are treated with steroidogenic inhibitors, such as metyrapone, ketoconazole, osilodrostat, and mitotane. Pituitary radiotherapy and bilateral adrenalectomy are performed when other treatments are not effective.

Read more at https://cushings.invisionzone.com/topic/57649-hormones-and-high-blood-pressure-study-reveals-endocrine-culprits-and-targeted-treatments/

The higher IGF-1 index was independently associated with lower prevalence of low bone mass in young CD patients, and IGF-1 might play an important role in the pathogenesis of CD-caused low bone mass.

Read more at https://cushings.invisionzone.com/topic/57619-association-of-igf-1-level-with-low-bone-mass-in-young-patients-with-cushing%E2%80%99s-disease/

Ectopic Cushing’s syndrome due to metastatic neuroendocrine small-cell carcinoma is a rare condition with a poor prognosis. The options for treatment are few and not necessarily curative. There needs to be increased awareness of this serious and rare complication. Managing the condition can be a challenge and requires a multidisciplinary team approach to improve outcomes.

Read more at https://cushings.invisionzone.com/topic/57577-recurrent-neuroendocrine-tumor-of-the-cervix-presenting-with-ectopic-cushing%E2%80%99s-syndrome/

I had the opportunity to be in both Fair Oaks Emergency Room and the hospital in Fairfax, VA over the last couple days.  Whenever a nurse/medical tech mentioned steroids, I asked what they knew about Cushing's.  One asked if it was a medication.  DUH!…

Read more at https://cushings.invisionzone.com/topic/57694-spreading-the-word/

Cushing's disease causes numerous metabolic disorders, cognitive decline, and sarcopenia, leading to deterioration of the general health in older individuals. Cushing's disease can be treated with transsphenoidal surgery, but thus far, surgery has often been avoided in older patients.

Read more at https://cushings.invisionzone.com/topic/57005-transsphenoidal-surgery-in-an-older-patient-with-cushings-disease/

Among 89 patients enrolled in this study (median age, 51 years), 21 showed clinical signs of Cushing syndrome (overt hypercortisolism) and 68 did not show clinical presentations (subclinical hypercortisolism).

Read more at https://cushings.invisionzone.com/topic/57584-association-between-aldosterone-and-hypertension-among-patients-with-overt-and-subclinical-hypercortisolism/

Cushing’s disease may sometimes make you feel that your life is out of your control. But there are some general things you can do to help take back control.

https://cushings-help.com/2024/11/05/tips-for-living-with-cushings/

At diagnosis, CS patients have elevated WBC, neutrophils, and NLR compared to controls. Remission does not normalize WBC levels in all patients, and baseline leukocytosis predicts a poorer remission prognosis in CD.

https://cushings.invisionzone.com/topic/57797-leukocytosis-in-cushing%E2%80%99s-syndrome-persists-post-surgical-remission-and-could-predict-a-lower-remission-prognosis-in-patients-with-cushing%E2%80%99s-disease/

Join NADF for the first annual virtual conference for patients and caregivers, 'Navigating Adrenal Health'. With talks on topics ranging from research updates to accessing patient resources to EMS standards and expectations, participants can prepare for a wealth of information for patients, caregivers, and clinicians alike.

https://cushings.invisionzone.com/topic/57871-webinar-navigating-adrenal-health/

The success and outcomes of repeat endoscopic transsphenoidal surgery (ETS) for residual or recurrent Cushing's disease (CD) are underreported in the literature. This study aims to address this gap by assessing the safety, feasibility, and efficacy of repeat ETS in these patients.

Read more at https://cushings.invisionzone.com/topic/57729-repeat-endoscopic-endonasal-transsphenoidal-surgery-for-residual-or-recurrent-cushings-disease-safety-feasibility-and-success/

Graphic Era Hospital has achieved a remarkable mileston by successfully treating two complex cases of the rare hormonal disorder Cushing’s Disease in Dehradun. The hospital’s experts used advanced technology and surgical skills to give the patients a new lease on life, marking this significant achievement.

https://cushings.invisionzone.com/topic/57868-graphic-era-hospital%E2%80%99s-milestone-treatment-of-two-complex-cases/

Posterior pituitary tumors (PPTs) are extremely rare, with fewer than 400 cases reported to date. In 2022, the WHO classified four types of tumors originating from the posterior pituitary

Read more at https://cushings.invisionzone.com/topic/57780-oncocytic-pituicytoma-in-a-patient-with-cushings-disease/

Pituitary radiotherapy (RT) is used for persistent/recurrent Cushing's disease (CD) after pituitary surgery. The utility of late-night salivary cortisol (LNSC) in evaluating endocrine remission after RT is unclear.

https://cushings.invisionzone.com/topic/57829-the-role-of-late-night-salivary-cortisol-in-the-assessment-of-endocrine-remission-in-patients-with-cushings-disease-after-pituitary-radiotherapy/

Cortisol testing is not routinely done during medical check-ups, and there currently aren’t any at-home tests available to assess cortisol levels. Most healthcare providers only recommend testing for cortisol if there are symptoms indicative of conditions like Cushing’s syndrome.

https://cushings.invisionzone.com/topic/57776-understanding-cortisol-the-stress-hormone-explained/

Paediatric endogenous Cushing syndrome is a rare condition with variable signs and symptoms of presentation. We studied a large cohort of paediatric patients with endogenous Cushing syndrome with the aim of describing anthropometric, clinical, and biochemical characteristics as well as associated complications and outcomes to aid diagnosis, treatment, and management.

Read more at https://cushings.invisionzone.com/topic/57686-paediatric-cushing-syndrome-prospective-multisite-observational-cohort-study/

Cushing’s syndrome, a clinical condition characterized by hypercortisolemia, exhibits distinct clinical signs and is associated with cyclic cortisol secretion in some patients. The clinical presentation of cyclic Cushing’s syndrome can be ambiguous and its diagnosis is often challenging.

Read more at https://cushings.invisionzone.com/topic/57745-evaluating-the-usefulness-of-plasma-chromogranin-a-measurement-in-cyclic-acth-dependent-cushing%E2%80%99s-syndrome/

We present a 9-year-old boy who presented at age 4 with cyclical Cushing syndrome and was eventually diagnosed with a novel, previously unreported, unpublished variant in PRKAR1A associated with Carney complex. He was treated with unilateral left adrenalectomy. At 1-year follow-up, he continues to be in remission of his symptoms of Cushing syndrome.

https://cushings.invisionzone.com/topic/57870-unilateral-adrenalectomy-for-pediatric-cyclical-cushing-syndrome-with-novel-prkar1a-variant-associated-carney-complex/

Cushing’s disease (CD) is associated with a specific form of metabolic syndrome that includes visceral obesity, which may affect cardiovascular hemodynamics by stimulating hypercortisolism-related metabolic activity. The purpose of this study was to evaluate the relationship between obesity and the hemodynamic profile of patients with CD. 

Read more at https://cushings.invisionzone.com/topic/57719-obesity-related-hemodynamic-alterations-in-patients-with-cushing%E2%80%99s-disease/

Blood tests and an MRI confirmed that Yawn had a tumour in her pituitary gland — a small, pea-sized organ at the base of the brain — that caused the gland to release excess adrenocorticotropic hormones. As a result, she became inundated with cortisol, a steroid the body releases in response to danger or stress. This combination of factors led to her diagnosis — Cushing’s disease.https://cushings.invisionzone.com/topic/57014-basics-what-is-cushings-disease/

Double pituitary adenomas are rare presentations of two distinct adenohypophyseal lesions seen in <1% of surgical cases. Increased rates of recurrence or persistence are reported in the resection of Cushing microadenomas and are attributed to the small tumor size and localization difficulties.

Read more at https://cushings.invisionzone.com/topic/57674-consecutive-resections-of-double-pituitary-adenoma-for-resolution-of-cushing-disease/

Prolonged cortisol exposure may promote cancer development and growth. Epidemiological research showed that extended glucocorticoids use is associated with elevated overall cancer risk. Recently, several studies suggested that cortisol levels increase cancer risk in patients with endogenous Cushing’s syndrome (CS).

https://cushings.invisionzone.com/topic/57854-predictors-of-cancer-in-patients-with-endogenous-cushing%E2%80%99s-syndrome/

The most common cause of Cushing syndrome (CS) is exposure to exogenous glucocorticoids. There is an increasing incidence of adulterated over-the-counter (OTC) supplements containing steroids.

Read more at https://cushings.invisionzone.com/topic/57624-exogenous-cushing-syndrome-and-hip-fracture-due-to-over-the-counter-supplement-artri-king/

The higher IGF-1 index was independently associated with lower prevalence of low bone mass in young CD patients, and IGF-1 might play an important role in the pathogenesis of CD-caused low bone mass.

Read more at https://cushings.invisionzone.com/topic/57619-association-of-igf-1-level-with-low-bone-mass-in-young-patients-with-cushing%E2%80%99s-disease/

The AI system analyzed video of more than 200 pituitary gland tumor operations, and gained around 10 years-worth of experience in a fraction of the time.

Read more at https://cushings.invisionzone.com/topic/57650-how-ai-could-help-make-brain-surgery-safer/

Ectopic Cushing’s syndrome due to metastatic neuroendocrine small-cell carcinoma is a rare condition with a poor prognosis. The options for treatment are few and not necessarily curative. There needs to be increased awareness of this serious and rare complication. Managing the condition can be a challenge and requires a multidisciplinary team approach to improve outcomes.

Read more at https://cushings.invisionzone.com/topic/57577-recurrent-neuroendocrine-tumor-of-the-cervix-presenting-with-ectopic-cushing%E2%80%99s-syndrome/

Café-au-lait skin macules, Cushing syndrome (CS), hyperthyroidism, and liver and cardiac dysfunction are presenting features of neonatal McCune–Albright syndrome (MAS), CS being the rarest endocrine feature. Although spontaneous resolution of hypercortisolism has been reported, outcome is usually unfavorable. While a unified approach to diagnosis, treatment, and follow-up is lacking, herein successful treatment and long-term follow-up of a rare case is presented.

Read more at https://cushings.invisionzone.com/topic/57628-severe-mccune%E2%80%93albright-syndrome-presenting-with-neonatal-cushing-syndrome-navigating-through-clinical-obstacles/

Cushing’s disease may sometimes make you feel that your life is out of your control. But there are some general things you can do to help take back control.

https://cushings-help.com/2024/11/05/tips-for-living-with-cushings/

Join NADF for the first annual virtual conference for patients and caregivers, 'Navigating Adrenal Health'. With talks on topics ranging from research updates to accessing patient resources to EMS standards and expectations, participants can prepare for a wealth of information for patients, caregivers, and clinicians alike.

https://cushings.invisionzone.com/topic/57871-webinar-navigating-adrenal-health/

Graphic Era Hospital has achieved a remarkable mileston by successfully treating two complex cases of the rare hormonal disorder Cushing’s Disease in Dehradun. The hospital’s experts used advanced technology and surgical skills to give the patients a new lease on life, marking this significant achievement.

https://cushings.invisionzone.com/topic/57868-graphic-era-hospital%E2%80%99s-milestone-treatment-of-two-complex-cases/

Cushing’s disease (CD) poses significant challenges in its treatment due to the lack of reliable biomarkers for predicting tumor localization or postoperative clinical outcomes. Sphingosine-1-phosphate (S1P) has been shown to increase cortisol biosynthesis and is regulated by adrenocorticotropic hormone (ACTH).

Read more at https://cushings.invisionzone.com/topic/57667-interpetrosal-sphingosine-1-phosphate-ratio-predicting-cushing%E2%80%99s-disease-tumor-laterality-and-remission-after-surgery/

Posterior pituitary tumors (PPTs) are extremely rare, with fewer than 400 cases reported to date. In 2022, the WHO classified four types of tumors originating from the posterior pituitary

Read more at https://cushings.invisionzone.com/topic/57780-oncocytic-pituicytoma-in-a-patient-with-cushings-disease/

Pituitary tumors can vary widely in severity, with some requiring surgical intervention. While certain pituitary tumors are more straightforward to remove, those that extend beyond the medial wall of the cavernous sinus (MWCS) are considered complex. A delicate region near the pituitary gland, the MWCS contains critical structures like cranial nerves and the carotid artery, which present additional surgical challenges.

https://cushings.invisionzone.com/topic/57830-new-advances-for-treating-complex-pituitary-tumors/

The hormone cortisol is produced by the adrenal glands, so adrenal insufficiency (also called Addison’s disease) is caused when the adrenal glands do not produce cortisol normally. Low cortisol can actually cause anxiety and depression, so some patients may really have anxiety — though doctors need to do further testing and/or evaluation to see that it is caused by their hormone levels, not a mental illness.

https://cushings.invisionzone.com/topic/57767-adrenal-insufficiency-may-be-misdiagnosed-as-anxiety/

The annual Pituitary Patient Education Day is a free event that features presentations from Johns Hopkins pituitary experts.

https://cushings.invisionzone.com/topic/57826-johns-hopkins-pituitary-patient-education-day/

We present a 9-year-old boy who presented at age 4 with cyclical Cushing syndrome and was eventually diagnosed with a novel, previously unreported, unpublished variant in PRKAR1A associated with Carney complex. He was treated with unilateral left adrenalectomy. At 1-year follow-up, he continues to be in remission of his symptoms of Cushing syndrome.

https://cushings.invisionzone.com/topic/57870-unilateral-adrenalectomy-for-pediatric-cyclical-cushing-syndrome-with-novel-prkar1a-variant-associated-carney-complex/

Dr. Correa has special expertise in transgender medicine; neuroendocrinology; and caring for adults with adrenal disorders, such as Cushing's syndrome, Addison's disease, primary hyperaldosteronism, neuroendocrine tumors, and rare endocrine conditions.

Read more at https://cushings.invisionzone.com/topic/57652-helpful-doctors-ricardo-correa/

The most common cause of Cushing syndrome (CS) is exposure to exogenous glucocorticoids. There is an increasing incidence of adulterated over-the-counter (OTC) supplements containing steroids.

Read more at https://cushings.invisionzone.com/topic/57624-exogenous-cushing-syndrome-and-hip-fracture-due-to-over-the-counter-supplement-artri-king/

Sequential treatment with ketoconazole to lower cortisol levels followed by octreotide to maintain biochemical remission according to UFC may be effective in a subset of patients with mild Cushing's Disease, suggesting that cortisol-mediated suppression of SST2 expression is a reversible process. 

https://cushings.invisionzone.com/topic/57843-a-prospective-trial-with-ketoconazole-induction-therapy-and-octreotide-maintenance-treatment-for-cushings-disease/

The higher IGF-1 index was independently associated with lower prevalence of low bone mass in young CD patients, and IGF-1 might play an important role in the pathogenesis of CD-caused low bone mass.

Read more at https://cushings.invisionzone.com/topic/57619-association-of-igf-1-level-with-low-bone-mass-in-young-patients-with-cushing%E2%80%99s-disease/

Pituitary tumors start in the pituitary gland. They’re usually benign (not cancerous) and rarely spread to other parts of the body. Dr. Borghei-Razavi discusses pituitary tumors and treatments through minimally invasive surgical approaches offered at Cleveland Clinic Florida.

Read more at https://cushings.invisionzone.com/topic/55668-pituitary-tumors-and-treatments/

CHI Memorial Medical Group announces the opening of CHI Memorial Endocrinology Associates, a practice that provides comprehensive medical management and care for conditions like type 1 and 2 diabetes, thyroid disease, thyroid cancer and a range of metabolic, pituitary and adrenal disorders.

The practice will be led by Prashanth Sekhar, MD, a fellowship trained endocrinologist with more than 10 years’ experience helping individuals with hormone-related conditions and diseases.

Read more at https://cushings.invisionzone.com/topic/56496-new-helpful-endo-in-tennessee/

Ectopic Cushing’s syndrome due to metastatic neuroendocrine small-cell carcinoma is a rare condition with a poor prognosis. The options for treatment are few and not necessarily curative. There needs to be increased awareness of this serious and rare complication. Managing the condition can be a challenge and requires a multidisciplinary team approach to improve outcomes.

Read more at https://cushings.invisionzone.com/topic/57577-recurrent-neuroendocrine-tumor-of-the-cervix-presenting-with-ectopic-cushing%E2%80%99s-syndrome/

Cushing’s disease may sometimes make you feel that your life is out of your control. But there are some general things you can do to help take back control.

https://cushings-help.com/2024/11/05/tips-for-living-with-cushings/

Join NADF for the first annual virtual conference for patients and caregivers, 'Navigating Adrenal Health'. With talks on topics ranging from research updates to accessing patient resources to EMS standards and expectations, participants can prepare for a wealth of information for patients, caregivers, and clinicians alike.

https://cushings.invisionzone.com/topic/57871-webinar-navigating-adrenal-health/

Patients with Cushing syndrome (CS) are at increased risk of venous thromboembolism.

Read more at https://cushings.invisionzone.com/topic/57730-venous-thromboembolism-in-cushing-syndrome/

Even after pituitary surgery, Cushing's Disease patients faced a higher hazard of complications, especially psychiatric hospitalizations and sepsis.

Read more at https://cushings.invisionzone.com/topic/57746-longterm-outcomes-in-patients-with-cushing%E2%80%99s-disease-vs-non-functioning-pituitary-adenoma-after-pituitary-surgery-an-active-comparator-cohort-study/

Cushing’s disease (CD), caused by an adrenocorticotropic hormone-secreting pituitary adenoma, is challenging to diagnose, especially in obese patients post-bariatric surgery. 

This report discusses a misdiagnosed case of CD in a 42-year-old obese male with hypertension. CD was suspected only after surgery, confirmed by magnetic resonance imaging (MRI) showing a pituitary macroadenoma.

https://cushings.invisionzone.com/topic/57844-challenges-of-cushings-syndrome-and-bariatric-surgery/

Graphic Era Hospital has achieved a remarkable mileston by successfully treating two complex cases of the rare hormonal disorder Cushing’s Disease in Dehradun. The hospital’s experts used advanced technology and surgical skills to give the patients a new lease on life, marking this significant achievement.

https://cushings.invisionzone.com/topic/57868-graphic-era-hospital%E2%80%99s-milestone-treatment-of-two-complex-cases/

Posterior pituitary tumors (PPTs) are extremely rare, with fewer than 400 cases reported to date. In 2022, the WHO classified four types of tumors originating from the posterior pituitary

Read more at https://cushings.invisionzone.com/topic/57780-oncocytic-pituicytoma-in-a-patient-with-cushings-disease/

I am thankful, believe it or not, that I had Cushing’s. Mind you, I wouldn’t want to have it now, although diagnoses and surgeries seem “easier” now.

Having Cushing’s taught me a lot, including how to stick up for myself, how to read medical books to learn more about my disease, how to do web design, how to navigate NIH. It taught me patience, how to make phone calls. It brought me a lot of new friends.

Read more at https://www.maryo.co/giving-thanks-day-19-2/

A 53-year-old woman with a history of metastatic small-cell lung cancer was evaluated during an inpatient admission for Cushing’s syndrome on the basis of new findings of hypertension, hypokalemia, hyperglycemia, and metabolic alkalosis.

https://cushings.invisionzone.com/topic/57798-thin-skin-in-cushing%E2%80%99s-syndrome/

We present a 9-year-old boy who presented at age 4 with cyclical Cushing syndrome and was eventually diagnosed with a novel, previously unreported, unpublished variant in PRKAR1A associated with Carney complex. He was treated with unilateral left adrenalectomy. At 1-year follow-up, he continues to be in remission of his symptoms of Cushing syndrome.

https://cushings.invisionzone.com/topic/57870-unilateral-adrenalectomy-for-pediatric-cyclical-cushing-syndrome-with-novel-prkar1a-variant-associated-carney-complex/

The February 2022 issue of Reader's Digest has information about a pituitary Cushing's patient.

Read the article at https://cushings.invisionzone.com/topic/56500-from-this-months-readers-digest/

The new 'pulsatility' therapy, the culmination of ten years' research by the Bristol team, is designed to deliver standard hydrocortisone replacement to patients via a pump which replicates more closely cortisol's natural rhythmic secretion pattern. The pulsatile subcutaneous pump has now revealed promising results in its first clinical trial.

Read more at https://cushings.invisionzone.com/topic/57651-first-of-its-kind-hormone-replacement-treatment-shows-promise-in-patient-trials/

The most common cause of Cushing syndrome (CS) is exposure to exogenous glucocorticoids. There is an increasing incidence of adulterated over-the-counter (OTC) supplements containing steroids.

Read more at https://cushings.invisionzone.com/topic/57624-exogenous-cushing-syndrome-and-hip-fracture-due-to-over-the-counter-supplement-artri-king/

The higher IGF-1 index was independently associated with lower prevalence of low bone mass in young CD patients, and IGF-1 might play an important role in the pathogenesis of CD-caused low bone mass.

Read more at https://cushings.invisionzone.com/topic/57619-association-of-igf-1-level-with-low-bone-mass-in-young-patients-with-cushing%E2%80%99s-disease/

Any condition that causes the adrenal gland to produce excessive cortisol results in the disorder Cushing's syndrome. Cushing syndrome is characterized by facial and torso obesity, high blood pressure, stretch marks on the belly, weakness, osteoporosis, and facial hair growth in females.

Read more at https://cushings.invisionzone.com/topic/56281-basics-cushings-syndrome-vs-cushings-disease/

Ectopic Cushing’s syndrome due to metastatic neuroendocrine small-cell carcinoma is a rare condition with a poor prognosis. The options for treatment are few and not necessarily curative. There needs to be increased awareness of this serious and rare complication. Managing the condition can be a challenge and requires a multidisciplinary team approach to improve outcomes.

Read more at https://cushings.invisionzone.com/topic/57577-recurrent-neuroendocrine-tumor-of-the-cervix-presenting-with-ectopic-cushing%E2%80%99s-syndrome/

Like most everything else in my life, having had Cushing's (pituitary) made this surgery more difficult.  My surgeon had to plan with my endocrinologist how much cortisol I'd need during the operation, then I had to stay overnight to get me successfully weaned off the cortisone again.

Read more at https://cushings.invisionzone.com/topic/57682-what-was-the-most-memorable-thing-that-happened-to-you-last-year/

Development of autoimmune disease was more common in patients with surgical remission of Cushing's disease than in those with surgically treated nonfunctioning pituitary adenomas (NFPAs), according to a retrospective matched cohort study.

Read more at https://www.medpagetoday.com/endocrinology/generalendocrinology/108801?

Cushing’s syndrome is a constellation of features occurring due to high blood cortisol levels. We report a case of a 47-year-old male with a history of recurrent olfactory neuroblastoma (ONB). He presented with bilateral lower limb weakness and anosmia and was found to have Cushing’s syndrome due to high adrenocorticotropic hormone (ACTH) levels from an ectopic source, ONB in this case. Serum cortisol and ACTH levels declined after tumor removal.

Read more at https://cushings.invisionzone.com/topic/57704-olfactory-neuroblastoma-causing-cushing%E2%80%99s-syndrome-due-to-the-ectopic-adrenocorticotropic-hormone-acth-secretion/

Cushing’s disease may sometimes make you feel that your life is out of your control. But there are some general things you can do to help take back control.

https://cushings-help.com/2024/11/05/tips-for-living-with-cushings/

Join NADF for the first annual virtual conference for patients and caregivers, 'Navigating Adrenal Health'. With talks on topics ranging from research updates to accessing patient resources to EMS standards and expectations, participants can prepare for a wealth of information for patients, caregivers, and clinicians alike.

https://cushings.invisionzone.com/topic/57871-webinar-navigating-adrenal-health/

Acute adrenal crisis is a life-threatening state caused by insufficient levels of cortisol, which is a hormone produced and released by the adrenal gland.

Read more at https://cushings.invisionzone.com/topic/56238-call-911-adrenal-crisis-addisonsadrenal-insufficiency/

Graphic Era Hospital has achieved a remarkable mileston by successfully treating two complex cases of the rare hormonal disorder Cushing’s Disease in Dehradun. The hospital’s experts used advanced technology and surgical skills to give the patients a new lease on life, marking this significant achievement.

https://cushings.invisionzone.com/topic/57868-graphic-era-hospital%E2%80%99s-milestone-treatment-of-two-complex-cases/

People with Cushing’s syndrome are at an increased risk of developing impaired glucose tolerance and hyperglycemia as a result of increased levels of cortisol throughout the body…

Approximately 10% to 30% of people with Cushing’s syndrome will develop impaired glucose tolerance, while 40% to 45% will develop diabetes.

Read more at https://cushings.invisionzone.com/topic/55671-what-causes-blood-sugar-to-rise-in-non-diabetics/

“My absolute favorite MD. Dr. Maas gets to know her patients and is very thorough. Dr. Maas gave me my life back and I will always love her for that. If you want a great Endocrinologist, she’s your best bet.” – Veronica M.

Read more at https://cushings.invisionzone.com/topic/56235-helpful-doctors-wisconsin/

Posterior pituitary tumors (PPTs) are extremely rare, with fewer than 400 cases reported to date. In 2022, the WHO classified four types of tumors originating from the posterior pituitary

Read more at https://cushings.invisionzone.com/topic/57780-oncocytic-pituicytoma-in-a-patient-with-cushings-disease/