Patients with neuroendocrine tumors before ectopic Cushing syndrome development were more likely metastatic and had worse survival

Read more at https://cushings.invisionzone.com/topic/56894-management-of-adrenocorticotropic-hormone-secreting-neuroendocrine-tumors-and-the-role-of-bilateral-adrenalectomy-in-ectopic-cushing-syndrome/

Ectopic Cushing’s syndrome due to metastatic neuroendocrine small-cell carcinoma is a rare condition with a poor prognosis. The options for treatment are few and not necessarily curative. There needs to be increased awareness of this serious and rare complication. Managing the condition can be a challenge and requires a multidisciplinary team approach to improve outcomes.

Read more at https://cushings.invisionzone.com/topic/57577-recurrent-neuroendocrine-tumor-of-the-cervix-presenting-with-ectopic-cushing%E2%80%99s-syndrome/

“The pituitary is commonly referred to as the ‘master’ gland because it does so many important jobs in the body,” says Karen Frankwich, MD, a board-certified endocrinologist at Mission Hospital. “Not only does the pituitary make its own hormones, but it also triggers hormone production in other glands. The pituitary is aided in its job by the hypothalamus. This part of the brain is situated above the pituitary, and sends messages to the gland on when to release or stimulate production of necessary hormones.”

Read more at https://cushings.invisionzone.com/topic/56334-the-pituitary-gland-small-but-mighty/

Read more at https://cushings.invisionzone.com/topic/57594-complete-and-sustained-remission-of-hypercortisolism-with-pasireotide-treatment-of-an-adrenocorticotropic-hormone-acth-secreting-thoracic-neuroendocrine-tumour-an-n-of-1-trial/

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Stress-related brain disorders can be associated with glucocorticoid disturbance and hippocampal alteration. However, it remains largely unknown how cortisol affects the structure and function of hippocampus. Cushing's disease (CD) provides a unique “hyperexpression model” to explore the effects of excessive cortisol on hippocampus as well as the relation between these effects and neuropsychological deficits.

Read more at https://cushings.invisionzone.com/topic/56924-altered-hippocampal-volume-and-functional-connectivity-in-patients-with-cushings-disease/

Cushing’s disease (CD) is a serious endocrine disorder caused by an adrenocorticotropic hormone (ACTH)-secreting pituitary neuroendocrine tumor (PitNET) that stimulates the adrenal glands to overproduce cortisol. Chronic exposure to excess cortisol has detrimental effects on health, including increased stroke rates, diabetes, obesity, cognitive impairment, anxiety, depression, and death. The first-line treatment for CD is pituitary surgery. Current surgical remission rates reported in only 56% of patients depending on several criteria. The lack of specificity, poor tolerability, and low efficacy of the subsequent second-line medical therapies make CD a medical therapeutic challenge. One major limitation that hinders the development of specific medical therapies is the lack of relevant human model systems that recapitulate the cellular composition of PitNET microenvironment.

Read more at https://cushings.invisionzone.com/topic/57575-development-of-human-pituitary-neuroendocrine-tumor-organoids-to-facilitate-effective-targeted-treatments-of-cushing%E2%80%99s-disease/

I have often said, I wish I had cancer instead.  Most people would not understand this sentiment, why in the world would you wish for such a horrible disease?...

Read more at https://cushieblogger.com/2019/04/04/from-a-past-blogging-challenge-cushings-awareness-challenge-danielle-day-4/

Cushing’s syndrome due to ectopic adrenocorticotropic hormone (ACTH) secretion (EAS) by a pheochromocytoma is a challenging condition. 

Read more at https://cushings.invisionzone.com/topic/57606-catastrophic-acth-secreting-pheochromocytoma/

Cushing’s disease is a progressive pituitary disorder in which there is an excess of cortisol in the body. While the disease can be treated surgically, this option is not possible for all patients. This is one of the approved medications that assist in controlling cortisol levels in people with Cushing’s disease.

Isturisa was approved in 2020 to treat adults with Cushing’s disease for whom pituitary surgery is ineffective or not an option.

Read more at https://cushings.invisionzone.com/topic/56571-meds-isturisa/

Ectopic pituitary adenoma (EPA) is a pituitary adenoma unrelated to the intrasellar component and is an extremely rare disease.

Read more at https://cushings.invisionzone.com/topic/57535-ectopic-adrenocorticotropic-hormone-secreting-pituitary-adenoma-in-the-clivus-region-a-case-report/

TSH stands for “thyroid stimulating hormone” and the test measures how much of this hormone is in your blood. TSH is produced by the pituitary gland in your brain. This gland tells your thyroid to make and release the thyroid hormones into your blood.

Read more at https://cushings.invisionzone.com/topic/56343-basics-testing-what-is-a-tsh-test/

Patients with neuroendocrine tumors before ectopic Cushing syndrome development were more likely metastatic and had worse survival

Read more at https://cushings.invisionzone.com/topic/56894-management-of-adrenocorticotropic-hormone-secreting-neuroendocrine-tumors-and-the-role-of-bilateral-adrenalectomy-in-ectopic-cushing-syndrome/

Ectopic Cushing’s syndrome due to metastatic neuroendocrine small-cell carcinoma is a rare condition with a poor prognosis. The options for treatment are few and not necessarily curative. There needs to be increased awareness of this serious and rare complication. Managing the condition can be a challenge and requires a multidisciplinary team approach to improve outcomes.

Read more at https://cushings.invisionzone.com/topic/57577-recurrent-neuroendocrine-tumor-of-the-cervix-presenting-with-ectopic-cushing%E2%80%99s-syndrome/

The founder of Adrenal Alternatives Foundation has suffered a severe adrenal crisis yesterday morning. She is alive but fighting for her life.
We are unsure of the status of the Foundation at this time.

This is the unfortunate reality of this disease, not even the strongest ones are exempt from the toll it takes. Keep fighting, adrenal warriors.

Read more at https://cushings.invisionzone.com/topic/57593-please-pray-for-the-founder-of-the-adrenal-alternatives-foundation/

This extended evaluation (EE) of the SONICS study assessed effects of levoketoconazole for an additional 6 months following open-label, 6-month maintenance treatment in endogenous Cushing’s syndrome.

Read more at https://cushings.invisionzone.com/topic/57576-levoketoconazole-treatment-in-endogenous-cushing%E2%80%99s-syndrome/

More from Facebook, 2022 - Janice said 'I’m so happy that you documented your life. And am grateful you gave up so Much of your life to raise awareness for our disease....If it weren’t for the support that you have provided all of us over the years life would be so Much more difficult. Thanks for everything you’ve done and continue to do'

Marie said 'Congrats
 to you on this special anniversary! I feel so honored and blessed to have met you on a few occasions and most grateful for your visit at NIH while I was there for 3 weeks. Thank you so much for your kindness and support! They meant alot to me!'

Judy said 'Thank you, thank you, thank you....'

Aemi said 'Amazing. Thank you for sharing your story and for continuing to educate doctors on Cushings!'

From https://cushingsbios.com/2021/11/03/maryo-34th-pituitary-surgery-anniversary/

Social media dominates most people's lives these days. You see what everyone you know is up to, but the problem is, most people only post about the highlights of their lives.

You don't get to see the low points, the every day struggles. You don't see what keeps them up at night with worry...

Read more at https://cushieblogger.com/2019/04/05/from-a-past-blogging-challenge-cushings-awareness-challenge-danielle-day-5/

This breaks my heart. Liz was so young. She was finally so hopeful after way too long. We have to do something to change this. People especially doctors have to know what we go through. Mary is one person and look at all she has done to raise awareness. We are so many. There has to be something we all can do. 

Read more at https://cushingsbios.com/2021/03/01/in-memory-liz-raftery-march-2012/

A 35-year-old woman is seen in the outpatient clinic for evaluation of an incidental pituitary macroadenoma. Her medical history is significant for hypertension, diabetes, hyperlipidemia, polycystic ovary syndrome, and obesity. She initially presented to the emergency department (ED) a week ago after an episode of right visual field changes that she described as waviness in her right eye and right hemibody sensory changes without motor deficits. While in the ED, she underwent a full workup for possible stroke, which was negative. Magnetic resonance imaging (MRI) of her brain without contrast revealed a 12-mm pituitary lesion; a repeat MRI with contrast was then ordered (Figure). No serum hormonal panel was available for review from ED records. 

Read more at https://cushings.invisionzone.com/topic/56643-workup-for-incidental-pituitary-adenoma/

Interview with Alicia, a Cushing’s Message Board member who is still testing. Alicia writes “Around the end of my Junior year, probably one of the worst things that could have happened during my 8 years of illness happened, I had severe psychiatric symptoms at school, including psychosis, and was put on a “students in crisis” plan and sent home for a little while. Being diagnosed as a “psych patient” would delay my diagnosis for years, most doctors just considered me “crazy.”

Read more at https://cushieblogger.com/2019/04/05/archived-interview-with-alicia-a-patient-who-is-still-testing/

The Add Your Bio form has been updated so that it no longer requires Flash. Your information will help others.

I would like to add that if anyone would like to do something for the Cushing's Awareness Challenge but you don't have (or want to have) a blog, why not consider adding your bio to the website this month?

More info at https://cushingsbios.com/2018/08/28/we-have-a-new-bio-form/

Add your location and diagnosis to our Cushing's World Map.
Helpful Doctor locations are being added to this map, as well

See the Map at https://drive.google.com/open?id=1NLdGqTJyaJOvxegUnUR_slLRcYyMsVbJ&usp=sharing

Patients with neuroendocrine tumors before ectopic Cushing syndrome development were more likely metastatic and had worse survival

Read more at https://cushings.invisionzone.com/topic/56894-management-of-adrenocorticotropic-hormone-secreting-neuroendocrine-tumors-and-the-role-of-bilateral-adrenalectomy-in-ectopic-cushing-syndrome/

Ectopic Cushing’s syndrome due to metastatic neuroendocrine small-cell carcinoma is a rare condition with a poor prognosis. The options for treatment are few and not necessarily curative. There needs to be increased awareness of this serious and rare complication. Managing the condition can be a challenge and requires a multidisciplinary team approach to improve outcomes.

Read more at https://cushings.invisionzone.com/topic/57577-recurrent-neuroendocrine-tumor-of-the-cervix-presenting-with-ectopic-cushing%E2%80%99s-syndrome/

Interview with Judy, the mother of two Cushing’s patients, and her daughter, Jess, a high school student with Cushing’s. Robin (staticnrg) hosted.

Read more at https://cushieblogger.com/2022/04/11/archived-interview-with-judy-mom-to-two-cushings-patients-and-her-daughter-jess-3/

Despite improved outcomes in recent years, increased mortality from CS persists. The causes of death highlight the need to prevent and manage co-morbidities in addition to treating hypercortisolism.

Read more at https://cushings.invisionzone.com/topic/56897-the-effect-of-endogenous-cushings-syndrome-on-all-cause-and-cause-specific-mortality/

Sharmyn McGraw knows as much about pituitary disease as some doctors. She learned about it after struggling for years with a medical mystery that began in 1993.

First, she began to feel anxious. Then, she began to gain weight, and she developed a rash. Much of her hair fell out. Her eyes began to yellow and her face puffed up.

Read more at https://cushings.invisionzone.com/topic/56898-tracking-a-mystery-disease-to-the-pituitary-gland-sharmyn-mcgraw/

Patients with neuroendocrine tumors before ectopic Cushing syndrome development were more likely metastatic and had worse survival

Read more at https://cushings.invisionzone.com/topic/56894-management-of-adrenocorticotropic-hormone-secreting-neuroendocrine-tumors-and-the-role-of-bilateral-adrenalectomy-in-ectopic-cushing-syndrome/

Ectopic Cushing’s syndrome due to metastatic neuroendocrine small-cell carcinoma is a rare condition with a poor prognosis. The options for treatment are few and not necessarily curative. There needs to be increased awareness of this serious and rare complication. Managing the condition can be a challenge and requires a multidisciplinary team approach to improve outcomes.

Read more at https://cushings.invisionzone.com/topic/57577-recurrent-neuroendocrine-tumor-of-the-cervix-presenting-with-ectopic-cushing%E2%80%99s-syndrome/

We describe the first report of recurrent Cushing's Disease that was quiescent during pregnancy and diagnosed in the immediate postpartum period. Understanding the risk and mechanisms of CD recurrence in pregnancy allows us to counsel these otherwise healthy, reproductive-age women in the context of additional family planning.

Read more at https://cushings.invisionzone.com/topic/57548-persistent-vs-recurrent-cushing%E2%80%99s-disease-diagnosed-four-weeks-postpartum/

Cushing’s syndrome (CS) is a rare condition of chronically elevated cortisol levels resulting in diverse comorbidities, many of which endure beyond successful treatment affecting the quality of life. Few data are available concerning patients’ experiences of diagnosis, care and persistent comorbidities.

Read more at https://cushings.invisionzone.com/topic/57550-unmet-needs-in-cushing%E2%80%99s-syndrome-the-patients/

Long-standing studies were conducted on vitamin D levels in patients with Cushing's Disease. Patients with CD, with and without osteopenia, were compared before and after oral calcium load showing that serum 1,25 (OH)2D3 plasma levels were higher in subjects with osteopenia than in those without it, likely due to a secondary increase in PTH levels as an effect of hypercortisolism [19]. Another study investigated the effect of hypercortisolism and eucortisolism, showing a reduction in serum 25(OH)D levels, but not in 1,25 (OH)2D3 in patients with hypercortisolism. 

Read more at https://cushings.invisionzone.com/topic/56652-vitamin-d-deficiency-in-cushing%E2%80%99s-disease-before-and-after-its-supplementation/

Patients with neuroendocrine tumors before ectopic Cushing syndrome development were more likely metastatic and had worse survival

Read more at https://cushings.invisionzone.com/topic/56894-management-of-adrenocorticotropic-hormone-secreting-neuroendocrine-tumors-and-the-role-of-bilateral-adrenalectomy-in-ectopic-cushing-syndrome/

I'm on a medication which interferes with the dexamethasone suppression tests. I tried going off the medication, but wasn't able to do so. I've taken saliva and 24 urine tests. I have many of the symptoms.

Read more here: https://cushings.invisionzone.com/topic/57202-difficulty-diagnosing-cushing-syndrome/

 In this CME Webinar, #endocrinology experts in the management of #CushingsDisease will describe best practices for the diagnosis and treatment to improve long-term outcomes for patients.

Read more at https://cushings.invisionzone.com/topic/57242-webinar-best-practices-for-the-management-of-individuals-with-cushings-disease/

Chronic insomnia can be a sign of Cushing’s syndrome, and doctors need be aware of this possibility, according to a case report of a woman diagnosed with Cushing’s shortly after seeking help for her insomnia.

This case also emphasized the usefulness of the dexamethasone suppression test in identifying the specific cause of Cushing’s.

Read more at https://cushings.invisionzone.com/topic/55648-chronic-insomnia-can-be-sign-of-cushing%E2%80%99s/

Ectopic Cushing’s syndrome due to metastatic neuroendocrine small-cell carcinoma is a rare condition with a poor prognosis. The options for treatment are few and not necessarily curative. There needs to be increased awareness of this serious and rare complication. Managing the condition can be a challenge and requires a multidisciplinary team approach to improve outcomes.

Read more at https://cushings.invisionzone.com/topic/57577-recurrent-neuroendocrine-tumor-of-the-cervix-presenting-with-ectopic-cushing%E2%80%99s-syndrome/

The founder of Adrenal Alternatives Foundation has suffered a severe adrenal crisis yesterday morning. She is alive but fighting for her life.
We are unsure of the status of the Foundation at this time.

This is the unfortunate reality of this disease, not even the strongest ones are exempt from the toll it takes. Keep fighting, adrenal warriors.

Read more at https://cushings.invisionzone.com/topic/57593-please-pray-for-the-founder-of-the-adrenal-alternatives-foundation/

Fact: NO! Caloric intake or lack of exercise has NO impact on weight gain and/ or loss in persons with Cushing’s...

Read more at https://cushieblogger.com/2022/04/09/cushings-myths-and-facts-cushings-syndrome-disease-can-be-healed-or-cured-2/

Listen as Jayne Kerns and Robin Smith (staticnrg) hosted a Cushing’s Awareness Day Special Chat.

Read more at https://cushieblogger.com/2022/04/08/archived-cushings-awareness-day-voice-chat-2/

I am currently struggling to get a Cushing's Diagnosis. I have all the symptoms, the weight gain, the striae, the fatigue, muscle issues, Buffalo hump, it all matches up, but my salivary cortisol tests and the  UFC I took also came back normal (It did not test for 17-OHS). My doctor's keep telling me it's PCOS despite the fact that my testosterone and androgen levels are well within normal. Do you have any advice for those trying to get diagnosed with episodic Cushing's? I am really struggling here.

read more at https://cushingsbios.com/2020/10/03/video-happy-girl-tells-her-story-so-far/

Patients with neuroendocrine tumors before ectopic Cushing syndrome development were more likely metastatic and had worse survival

Read more at https://cushings.invisionzone.com/topic/56894-management-of-adrenocorticotropic-hormone-secreting-neuroendocrine-tumors-and-the-role-of-bilateral-adrenalectomy-in-ectopic-cushing-syndrome/

We characterized the phenotype of a large cohort of patients with Cushing’s Disease, a rare condition associated with elevated cortisol levels. Results from hypercortisolemic patients with active Cushing’s were compared with those obtained from eucortisolemic patients after remission and from non-diseased volunteers.

Read more at https://cushings.invisionzone.com/topic/57255-hypercortisolemic-cushings-patients-possess-a-distinct-class-of-hematopoietic-progenitor-cells-leading-to-erythrocytosis/

Cushing’s syndrome is considered rare, but that may be because it is under-reported. As a result, we don’t have good estimates for how many people have it, which is why the estimates for the actual number of cases vary so much–from 5 to 28 million people. The most common age group that Cushing’s affects are those 20 to 50 years old.  It is thought that obesity, type 2 diabetes, and high blood pressure may increase your risk of developing this syndrome.

Read more at https://cushings.invisionzone.com/topic/56262-cushing%E2%80%99s-syndrome-a-tale-of-frequent-misdiagnosis/

…for Mary Kelly O'Connor and her diligence in creating a support group website that many of us feel was literally a lifesaver.

Read more at https://cushieblogger.com/testimonial/facebook/

A 37–year–old female presented with amenorrhea for the last year, associated with weight gain. She had a moon face, buffalo hump, and central obesity. A 24-hour urine collection for cortisol was performed, revealing elevated cortisol. Cortisol level was non-suppressed after administering dexamethasone. MRI of the pituitary revealed a pituitary microadenoma, and the CT scan of the abdomen with adrenal protocol revealed a left adrenal adenoma.

Read more at https://cushings.invisionzone.com/topic/56785-simultaneous-pituitary-and-adrenal-adenomas-in-a-patient-with-non-acth-dependent-cushing-syndrome/

Ectopic Cushing’s syndrome due to metastatic neuroendocrine small-cell carcinoma is a rare condition with a poor prognosis. The options for treatment are few and not necessarily curative. There needs to be increased awareness of this serious and rare complication. Managing the condition can be a challenge and requires a multidisciplinary team approach to improve outcomes.

Read more at https://cushings.invisionzone.com/topic/57577-recurrent-neuroendocrine-tumor-of-the-cervix-presenting-with-ectopic-cushing%E2%80%99s-syndrome/

Tumors arising in the pituitary gland show symptoms either due to excessive hormone secretion or due to excessive growth and compression and spread to the surrounding tissues. Adenomas that do not secrete hormones usually grow slowly and can remain asymptomatic for years. Those who secrete hormones show early symptoms due to the effects of hormones in the body…

Cushing's - In ACTH excess; fat in abnormal areas of the body, muscle weakness, high blood pressure and blood sugar, skin oily and acne development, stretch marks, psychological problems.

Read more at https://cushings.invisionzone.com/topic/55650-vision-loss-may-herald-brain-tumor/

More than three-quarters of adults with Cushing’s disease assigned osilodrostat had a normalized mean urinary free cortisol level at 12 weeks and maintained a normal level at 36 weeks.

Read more at https://cushings.invisionzone.com/topic/56787-osilodrostat-normalizes-urinary-free-cortisol-in-most-adults-with-cushing%E2%80%99s-disease/

Jen had Pituitary surgery by Dr. Shahinian 4/28/04, removed ACTH secreting corticotroph hyperplasia and prolactinoma.

Read more at https://cushieblogger.com/2022/04/09/archived-interview-jens-discussed-bilateral-adrenalectomy-bla-3/

Research opportunity for Human Growth Hormone Deficiency caregivers of adolescent patients.

This is a 75 min web-assisted phone interview, and the compensation is $125.

Read more at https://cushings.invisionzone.com/topic/56899-human-growth-hormone-study/

Dear friends and family:

I am writing this letter to share with you some basic facts about Cushing’s Disease/Syndrome and the recovery process so that you will have sufficient information to form realistic expectations about me and my ability to engage in certain activities in light of this disease and its aftermath.

As you know, Cushing’s is a rarely diagnosed endocrine disorder characterized by hypercortisolism. 

Read more at https://cushings.invisionzone.com/topic/56191-family-information-kate/

We describe the case of a patient with severe COVID-19 infection with active Cushing’s disease due to pituitary carcinoma, who was treated with high-dose dexamethasone followed by ‘block-replacement’ therapy with hydrocortisone in combination with off-label use of ketoconazole as a steroidogenesis inhibitor. His hospitalization was prolonged by multiple readmissions to the ICU for infectious causes. Our case illustrates the presence of multiple comorbidities for a severe and complicated course of COVID-19 in a patient with active Cushing’s disease.

Read more at https://cushings.invisionzone.com/topic/56658-covid-19-and-cushing%E2%80%99s-disease-in-a-patient-with-acth-secreting-pituitary-carcinoma/

Adults deficient in pituitary growth hormone have a unique phenotype. They develop central obesity and may have high blood pressure and lethargy. Growth hormone in adulthood is needed to maintain body homeostasis, i.e., the appropriate ratio between lean body mass and fat mass. When these GH-deficient adults [receive] very low doses of growth hormone, body changes are recalibrated and homeostatic changes that occur with hormone deficiency may be reversed.

Read more at https://cushings.invisionzone.com/topic/57571-an-adult-endocrine-misnomer-%E2%80%93-growth-hormone-in-adults/

Carlin is from the Napa Valley CA. USA.

I’m 66 yo and have recovered from Cushings but now take hydrocortisone, thyroxine, ddavp and citalopram. It’s was a real fight to find a dr who believed me. (my GP said I was a morbidly obese hypochondriac).

Read more at https://cushingsbios.com/2022/02/12/carlin-recovered-from-pituitary-tumor/

The endocrine system is a complex network of glands and organs. It uses hormones to control and coordinate your body's metabolism, energy level, reproduction, growth and development, and response to injury, stress, and mood. The following are integral parts of the endocrine system..

Read more at https://cushings.invisionzone.com/topic/56271-the-endocrine-system/

Patients with neuroendocrine tumors before ectopic Cushing syndrome development were more likely metastatic and had worse survival

Read more at https://cushings.invisionzone.com/topic/56894-management-of-adrenocorticotropic-hormone-secreting-neuroendocrine-tumors-and-the-role-of-bilateral-adrenalectomy-in-ectopic-cushing-syndrome/

Ectopic Cushing’s syndrome due to metastatic neuroendocrine small-cell carcinoma is a rare condition with a poor prognosis. The options for treatment are few and not necessarily curative. There needs to be increased awareness of this serious and rare complication. Managing the condition can be a challenge and requires a multidisciplinary team approach to improve outcomes.

Read more at https://cushings.invisionzone.com/topic/57577-recurrent-neuroendocrine-tumor-of-the-cervix-presenting-with-ectopic-cushing%E2%80%99s-syndrome/

This is a video is on the HPA Axis.

You may have to sign up/log in to view this video but Coursera is free – and you might find other courses of interest!

Read more at https://cushieblog.com/2015/02/06/hypothalamus-pituitary-adrenal-axis/

A chronic, progressive disease was discovered to be the reason why a man in his 20s experienced a sudden increase of gray hair and facial changes, local doctors said…

Doctors suspected he suffered from acromegaly, a chronic disease characterized by enlargement of head bones, soft parts of the feet and hands and sometimes other parts of the body due to excessive secretion of growth hormones by the pituitary gland.

Read more at https://cushings.invisionzone.com/topic/55649-chronic-disease-root-of-young-mans-abnormally-gray-hair-and-facial-changes/

Many people on the message boards see Dr. Kirschner for adrenal issues.

See the short video at https://cushings.invisionzone.com/topic/56786-helpful-doctors-ohio/

Per the terms of the settlement, Corcept (CORT) has allowed Hikma (OTCPK:HKMPF) the rights to market a generic version of Korlym from Oct. 01, 2034, or earlier subject to certain conditions.

Read more at https://cushings.invisionzone.com/topic/57582-korlym-corcept-settles-patent-dispute-with-hikma-over-cushing%E2%80%99s-syndrome-drug/

Read more at https://cushings.invisionzone.com/topic/57595-what-do-you-think-medical-gaslighting/

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There are many genetic varieties with quite a few discovered in the past couple of years. Plus, there are several types such as adrenal, ectopic, and pituitary. And so on...

Read more at https://cushieblogger.com/2021/04/10/cushings-myths-and-facts-all-types-of-cushings-are-the-same-3/

Compared with placebo, levoketoconazole improved cortisol control and serum cholesterol levels for adults with endogenous Cushing’s syndrome

Read more at https://cushings.invisionzone.com/topic/56902-levoketoconazole-improves-cortisol-control-in-endogenous-cushing%E2%80%99s-syndrome/

Pasireotide (PAS) is a novel somatostatin receptor ligands (SRL), used in controlling hormonal hypersecretion in both acromegaly and Cushing’s Disease (CD). In previous studies and meta-analysis, first-generation SRLs were reported to be able to induce significant tumor shrinkage only in somatotroph adenomas. 

Read more at https://cushings.invisionzone.com/topic/57267-pasireotide-induced-shrinkage-in-gh-and-acth-secreting-pituitary-adenoma/