The U.S. Food and Drug Administration today approved Isturisa (osilodrostat) oral tablets for adults with Cushing's disease who either cannot undergo pituitary gland surgery or have undergone the surgery but still have the disease. Cushing's disease is a rare disease in which the adrenal glands make too much of the cortisol hormone. Isturisa is the first FDA-approved drug to directly address this cortisol overproduction by blocking the enzyme known as 11-beta-hydroxylase and preventing cortisol synthesis.

Read more at https://cushieblog.com/2020/03/09/fda-approves-new-treatment-for-adults-with-cushings-disease/

Jen had Pituitary surgery by Dr. Shahinian 4/28/04, removed ACTH secreting corticotroph hyperplasia and prolactinoma.

Read more at https://cushieblogger.com/2018/04/09/interview-archive-jens-discussed-bilateral-adrenalectomy-bla/

For patients with persistent or recurring Cushing’s disease, monthly pasireotide therapy was safe and effective, leading to normal urinary free cortisol levels in 47% of patients after 2 years, according to findings published in Clinical Endocrinology.

Read more at https://cushieblog.com/2019/09/09/long-acting-pasireotide-provides-sustained-biochemical-improvements-in-cushings-disease/

Mike is from Carrollton, VA.  His adrenal glands aren't working so he has to take prednisone, which has now caused Cushing's.

Read more at https://cushingsbios.com/2019/09/12/mike-h-steroid-induced-cushings-bio/

Those with adrenal insufficiency fall into that category. When sick with a viral infection, they can have a more serious illness, and certainly require stress dose steroids to help to respond to the illness. If someone with adrenal insufficiency contracts the coronavirus, it is more likely to lead to the need for supportive care, including hospitalization.

Read more at http://cushings.invisionzone.com/topic/55070-update-on-coronavirus-covid-19/

Cushing's disease (CD) presents a marked female preponderance, but whether this skewed gender distribution has any relevance to the presentation and outcome of CD is not known.

Read more at https://cushieblog.com/2020/06/10/gender-related-differences-in-the-presentation-and-course-of-cushings-disease/

A member of the message board writes: 'I’ve just discovered this article two months ago and I was very pleased to speak directly to Dr. Gerardo Burton

He and his team developed a drug (21OH-6OP) which is a SPECIFIC antagonist for cortisol receptors, unlikely mifepristone which inhibits cortisol AND progesterone with so many undesired adverse effects.'

Read more at http://cushings.invisionzone.com/topic/55167-specific-cortisol-receptor-antagonist-created/?tab=comments#comment-475251

Sherry is from King, NC.  She is a 44 year old female started out with joint pain and gastrointestinal issues.  Her IPSS is scheduled for June 23, 2020 after an MRI revealed a pituitary tumor.

Read more at https://cushingsbios.com/2020/06/10/sherri-a-pituitary-bio/

We report a case of a 35-year-old patient diagnosed with Cushing’s syndrome complicated with an impaired glucose tolerance (IGT) and a severe psychiatric disturbance. The diagnosis of CNC was made by having two major criteria, namely a primary pigmented nodular adrenal disease (PPNAD) and thyroid carcinoma. 

Read more at https://cushieblog.com/2017/10/10/cushings-syndrome-revealing-carney-complex-a-case-report/

Robin had Cushing's for over 20 years, at least. Of course, no one figured it out or even put two and two together until her new PCP whom she found in 2004 said 'endocrine'. She didn't figure it out, either, but at least Robin had a piece of the puzzle and she found cushings-help.com. Robin immediately went into denial and left for several months until she got so sick she knew she had to have help. She had originally sought this PCP because she had been going to all sorts of doctors.

Read more at  https://cushieblogger.com/2020/04/13/mary-oconnor-maryo-second-archived-interview-with-robin-smith-staticnrg/

There are many genetic varieties with quite a few discovered in the past couple of years. Plus, there are several types such as adrenal, ectopic, and pituitary. And so on...

Read more at https://cushieblogger.com/2019/04/10/cushings-myths-and-facts-all-types-of-cushings-are-the-same/

The Add Your Bio form has been updated so that it no longer requires Flash. Your information will help others.

I would like to add that if anyone would like to do something for the Cushing's Awareness Challenge but you don't have (or want to have) a blog, why not consider adding your bio to the website this month?

More info at https://cushingsbios.com/2018/08/28/we-have-a-new-bio-form/

A guest on the Cushing's Help message boards asked:

Hi wondered if anyone could help me out - been suffering with these symptoms lately and wondered if cortisol could be the issue

Read more at https://cushieblogger.com/2020/05/11/can-you-help-possible-cushings-or-cortisol-issue/

(1858) Dutch physician Christiaan Eijkman was born. He demonstrated that beriberi is caused by a poor diet, which later led to the discovery that beriberi results from a vitamin B1 deficiency.

Add your own info (or your doctor's) to the Cushie MemberMap at https://cushieblogger.com/2018/11/17/rebuilding-the-membermap/

After Your Transsphenoidal (Pituitary) Surgery

After your physicians have determined that it is reasonably safe to discharge you from the hospital following transsphenoidal pituitary surgery there are a number of important situations that may arise. Most people feel well after discharge. However, you should be aware of these possible problems, just in case. The following general guidelines are provided to promote your health and safety.

Read more at http://www.cushings-info.com/index.php?title=Pituitary_Post-Op

Ashleigh is from Australia.  She was originally diagnosed with PCOS.  Her main symptoms before pituitary surgery were weight gain, bright red stretch marks, joint pains, muscle loss and fatigue.

Read more at https://cushingsbios.com/2019/09/12/ashleigh-pituitary-tumor-bio/

Listen as Robin Smith (staticnrg) and Mary O’Connor (MaryO) co-host Cushing’s message board members calling in to talk about their fight for diagnosis and treatment. The show will be opened with a brief explanation of what Cushing’s is and what the symptoms are.

Listen at https://cushieblogger.com/2020/04/12/archived-interview-cushings-diagnosis-and-symptoms-part-2/

Can I get blood results over ph and skip right to Endocrinologist if Cortisol is high? Any input of speeding this along?

Anyone else with only a few symptoms?

Read more at https://cushieblogger.com/2020/06/10/can-you-help-very-few-symptoms/

Sherry writes: Excellent Doctor, Takes his time, actively listens to his patients concerns and addresses questions in an easy to understand manner.

Read more at https://cushieblogger.com/2020/06/10/helpful-doctors-north-carolina/

Amy G is from Ogden, Utah..  She has been diagnosed with Cyclical Cushings Disease with Empty Sella Turcia.  1/4 sized damaged pituitary. She also has rare complications with my Cushings Disease and is having trouble finding the right doctors in Utah.

Read more at https://cushingsbios.com/2019/08/21/amy-g-cyclical-cushings-bio/

Karen’s disease started when she was a little girl (7) and she finally got a diagnosis in 2005. She had cycling Cushing’s, Thyroid disease, GH deficiency, and Auto immune Alopecia. She believes she is cured after two Pituitary surgeries. A doctor didn’t advise Vermont’s Karen Nolan (Rooon on the boards) that she might be one of the scant 3.5 per million people diagnosed annually with Cushing’s disease – another Cushing’s patient did.

Read more at https://cushieblogger.com/2019/04/12/archived-interview-karen-nolan-cyclic-cushings-part-2/

The Endocrine Society today (10/13/16) issued a Clinical Practice Guideline that recommends treating insufficient hormone levels in individuals with hypopituitarism by replacing hormones at levels as close to the body's natural patterns as possible.

Read more at https://cushieblog.com/2016/10/15/endocrine-society-issues-new-guidelines-on-hypopituitarism/

What should you do if an Addison crisis threatens? How do you prepare an emergency injection and how do you administer it? 

See the video clip at http://cushings.invisionzone.com/topic/55250-important-how-an-emergency-injection-works/

Here, we describe a human pilot trial of a soft, smart contact lens for real-time detection of the cortisol concentration in tears using a smartphone. 

Read more at https://cushieblog.com/2020/07/18/smart-soft-contact-lens-for-wireless-immunosensing-of-cortisol/

It has been two years since your post, and I hope that you are feeling better...

Read more at https://cushingsbios.com/2014/10/23/raveh-i-adrenal-bio/

Jenn (StaceyJenn) was diagnosed with adrenal insufficiency, hypothyroidism, and a host of other ailments in 2001 (candidiasis, intestinal permeability, 22 latent food allergies). Once diagnosed, she was on specially formulated hydrocortisone for 7 years as she was allergic to the fillers in the meds...

Listen at https://cushieblogger.com/2019/04/15/archived-interview-jenn-steroid-induced-iatrogenic-cushings-patient/